ID HIP37_ARATH Reviewed; 358 AA.
AC A2RVM8; O23124; Q8GYF2;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 37 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP37 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP37 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At1g23000 {ECO:0000312|Araport:AT1G23000};
GN ORFNames=F19G10.6 {ECO:0000312|EMBL:AAB72166.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:ABN04757.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-358.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB72166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC42327.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF000657; AAB72166.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30320.1; -; Genomic_DNA.
DR EMBL; BT030019; ABN04757.1; -; mRNA.
DR EMBL; AK117674; BAC42327.1; ALT_INIT; mRNA.
DR PIR; A86364; A86364.
DR RefSeq; NP_173713.1; NM_102148.4.
DR AlphaFoldDB; A2RVM8; -.
DR SMR; A2RVM8; -.
DR STRING; 3702.A2RVM8; -.
DR PaxDb; 3702-AT1G23000-1; -.
DR EnsemblPlants; AT1G23000.1; AT1G23000.1; AT1G23000.
DR GeneID; 838908; -.
DR Gramene; AT1G23000.1; AT1G23000.1; AT1G23000.
DR KEGG; ath:AT1G23000; -.
DR Araport; AT1G23000; -.
DR TAIR; AT1G23000; -.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_041066_0_0_1; -.
DR InParanoid; A2RVM8; -.
DR PRO; PR:A2RVM8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A2RVM8; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR45868; HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED; 1.
DR PANTHER; PTHR45868:SF19; HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 37; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..355
FT /note="Heavy metal-associated isoprenylated plant protein
FT 37"
FT /id="PRO_0000437851"
FT PROPEP 356..358
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437852"
FT DOMAIN 12..75
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 100..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 26
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT MOD_RES 355
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 355
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 358 AA; 39312 MW; 037642C678B49D2A CRC64;
MTKDEDFKLL KIQTFSLRVN IHCEGCNKKV KKLLQRIEGV CHVKIEAEHQ KVTVSGSVDS
ATLINKLVKA GKHAELWSPN PNQNQPQKPK TNDFIKNVNQ KGQKQGSAKS GIEACKPKNG
PKGAAFVAEE DGDGSEEEDG DVQFPKPANQ QQQQNVVNAK KNSGGAAMNN GNNGVNAASK
KVNQKQSNHN QNTQQVMAAM RMRTAGKMST GVEANEIGAL MGLAGFNGAT NAVNHPPNGI
QQQLQAPPLN NVNGVTNHNL TNSNGGMMMN MNGYNNHHPM NMQSRQMMHQ PQQMMYQRSS
FVPASSNGYY YNYTPSPYSY YPYYPYASDQ YQQQSSHSHA TNMSSEEDAG NNNSCNIM
//
