ID HIP4_ARATH Reviewed; 287 AA.
AC Q9SHQ8;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 24-JAN-2024, entry version 130.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 4 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP04 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP04 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At1g29000 {ECO:0000312|Araport:AT1G29000};
GN ORFNames=F1K23.4 {ECO:0000312|EMBL:AAF24557.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
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DR EMBL; AC007508; AAF24557.2; -; Genomic_DNA.
DR EMBL; CP002684; AEE31027.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58287.1; -; Genomic_DNA.
DR RefSeq; NP_001319102.1; NM_001332827.1.
DR RefSeq; NP_174195.1; NM_102641.2.
DR AlphaFoldDB; Q9SHQ8; -.
DR SMR; Q9SHQ8; -.
DR STRING; 3702.Q9SHQ8; -.
DR SwissPalm; Q9SHQ8; -.
DR PaxDb; 3702-AT1G29000-1; -.
DR ProteomicsDB; 230365; -.
DR EnsemblPlants; AT1G29000.1; AT1G29000.1; AT1G29000.
DR EnsemblPlants; AT1G29000.2; AT1G29000.2; AT1G29000.
DR GeneID; 839774; -.
DR Gramene; AT1G29000.1; AT1G29000.1; AT1G29000.
DR Gramene; AT1G29000.2; AT1G29000.2; AT1G29000.
DR KEGG; ath:AT1G29000; -.
DR Araport; AT1G29000; -.
DR TAIR; AT1G29000; -.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_039886_3_1_1; -.
DR InParanoid; Q9SHQ8; -.
DR OMA; KTHKMIE; -.
DR OrthoDB; 461294at2759; -.
DR PhylomeDB; Q9SHQ8; -.
DR PRO; PR:Q9SHQ8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHQ8; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 2.
DR InterPro; IPR044577; HIPP4/7/8/17/18/19.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46195:SF12; HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 4; 1.
DR PANTHER; PTHR46195; HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 7; 1.
DR Pfam; PF00403; HMA; 2.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR PROSITE; PS50846; HMA_2; 2.
PE 3: Inferred from homology;
KW Coiled coil; Lipoprotein; Metal-binding; Methylation; Prenylation;
KW Reference proteome; Repeat; Zinc.
FT CHAIN 1..284
FT /note="Heavy metal-associated isoprenylated plant protein
FT 4"
FT /id="PRO_0000437797"
FT PROPEP 285..287
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437798"
FT DOMAIN 14..80
FT /note="HMA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT DOMAIN 112..176
FT /note="HMA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 181..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 179..235
FT /evidence="ECO:0000255"
FT BINDING 25
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 28
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 123
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 126
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT MOD_RES 284
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 284
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 287 AA; 33411 MW; 7F59DE19A6F4E85A CRC64;
MGEEEEKKEK GDEIITAVYK VHLHCRKCAC DIKKPLLRFQ GVQNVDFDLE KNEIKVKGKI
EVVKIHKQIE KWSKKKVELI SPKPSEVKKT TTTTTTTSVV EKKTTEIKKD VIRTTVLKVH
IHCAQCDKDL QHKLLKHKAI HIVKTDTKAQ TLTVQGTIES AKLLAYIKKK VHKHAEIISS
KTEEEKKKEE EDKKKKEEED KKKKEDEKKK EEEKKKEEEN KKKEGEKKKE EVKVEVTTKT
ITQVVEYKEI VKVEGQKDKD GNIPYFVHYV YAPQLFSDEN PNACRIV
//
