ID HOP1_YEAST Reviewed; 605 AA.
AC P20050; D6VVL2;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 27-MAR-2024, entry version 168.
DE RecName: Full=Meiosis-specific protein HOP1;
GN Name=HOP1; OrderedLocusNames=YIL072W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=7234;
RX PubMed=2107981; DOI=10.1016/0092-8674(90)90216-2;
RA Hollingsworth N.M., Goetsch L., Byers B.;
RT "The HOP1 gene encodes a meiosis-specific component of yeast chromosomes.";
RL Cell 61:73-84(1990).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=8462842; DOI=10.1093/genetics/133.4.785;
RA Hollingsworth N.M., Johnson A.D.;
RT "A conditional allele of the Saccharomyces cerevisiae HOP1 gene is
RT suppressed by overexpression of two other meiosis-specific genes: RED1 and
RT REC104.";
RL Genetics 133:785-797(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Probable constituent of the synaptonemal complex during
CC meiosis. May interact with RED1.
CC -!- INTERACTION:
CC P20050; P14291: RED1; NbExp=3; IntAct=EBI-3768303, EBI-14909;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Synapsis of meiotic
CC chromosomes.
CC -!- DEVELOPMENTAL STAGE: Meiosis-specific.
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DR EMBL; J04877; AAA34682.1; -; Genomic_DNA.
DR EMBL; Z38060; CAA86151.1; -; Genomic_DNA.
DR EMBL; Z37997; CAA86098.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08478.1; -; Genomic_DNA.
DR PIR; A34691; A34691.
DR RefSeq; NP_012193.3; NM_001179422.3.
DR PDB; 5YYZ; X-ray; 1.80 A; B=312-324.
DR PDB; 8CWW; EM; 2.74 A; P=321-531.
DR PDBsum; 5YYZ; -.
DR PDBsum; 8CWW; -.
DR AlphaFoldDB; P20050; -.
DR SMR; P20050; -.
DR BioGRID; 34920; 72.
DR ComplexPortal; CPX-1387; Synaptonemal complex.
DR DIP; DIP-2371N; -.
DR IntAct; P20050; 1.
DR MINT; P20050; -.
DR STRING; 4932.YIL072W; -.
DR iPTMnet; P20050; -.
DR PaxDb; 4932-YIL072W; -.
DR PeptideAtlas; P20050; -.
DR EnsemblFungi; YIL072W_mRNA; YIL072W; YIL072W.
DR GeneID; 854738; -.
DR KEGG; sce:YIL072W; -.
DR AGR; SGD:S000001334; -.
DR SGD; S000001334; HOP1.
DR VEuPathDB; FungiDB:YIL072W; -.
DR eggNOG; KOG4652; Eukaryota.
DR GeneTree; ENSGT00390000018130; -.
DR HOGENOM; CLU_033649_0_0_1; -.
DR InParanoid; P20050; -.
DR OMA; MRLMFNE; -.
DR OrthoDB; 2915579at2759; -.
DR BioCyc; YEAST:G3O-31339-MONOMER; -.
DR BioGRID-ORCS; 854738; 4 hits in 10 CRISPR screens.
DR PRO; PR:P20050; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P20050; Protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:SGD.
DR GO; GO:0000800; C:lateral element; IPI:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000795; C:synaptonemal complex; NAS:ComplexPortal.
DR GO; GO:0000400; F:four-way junction DNA binding; IDA:SGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:SGD.
DR GO; GO:0035825; P:homologous recombination; NAS:ComplexPortal.
DR GO; GO:0051598; P:meiotic recombination checkpoint signaling; IGI:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; NAS:ComplexPortal.
DR GO; GO:0007130; P:synaptonemal complex assembly; IMP:SGD.
DR Gene3D; 3.30.900.10; HORMA domain; 1.
DR InterPro; IPR016573; Hop1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR48225; HORMA DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR48225:SF7; MEIOSIS-SPECIFIC PROTEIN HOP1; 1.
DR Pfam; PF02301; HORMA; 1.
DR PIRSF; PIRSF010751; HOP1_fungi; 1.
DR SUPFAM; SSF56019; The spindle assembly checkpoint protein mad2; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; DNA-binding; Meiosis; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..605
FT /note="Meiosis-specific protein HOP1"
FT /id="PRO_0000126123"
FT DOMAIN 20..250
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT ZN_FING 348..364
FT VARIANT 595
FT /note="S -> N (in allele HOP1-628; TS)"
SQ SEQUENCE 605 AA; 68876 MW; 9ED6EA30BE41B166 CRC64;
MSNKQLVKPK TETKTEITTE QSQKLLQTML TMSFGCLAFL RGLFPDDIFV DQRFVPEKVE
KNYNKQNTSQ NNSIKIKTLI RGKSAQADLL LDWLEKGVFK SIRLKCLKAL SLGIFLEDPT
DLLENYIFSF DYDEENNVNI NVNLSGNKKG SKNADPENET ISLLDSRRMV QQLMRRFIII
TQSLEPLPQK KFLTMRLMFN DNVDEDYQPE LFKDATFDKR ATLKVPTNLD NDAIDVGTLN
TKHHKVALSV LSAATSSMEK AGNTNFIRVD PFDLILQQQE ENKLEESVPT KPQNFVTSQT
TNVLGNLLNS SQASIQPTQF VSNNPVTGIC SCECGLEVPK AATVLKTCKS CRKTLHGICY
GNFLHSSIEK CFTCIFGPSL DTKWSKFQDL MMIRKVFRFL VRKKKGFPAS ITELIDSFIN
VEDQNNEVKE RVAFALFVFF LDETLCLDNG GKPSQTIRYV TSSVLVDVKG IVIPNTRKQL
NVNHEYKWHF TTSSPKAESF YQEVLPNSRK QVESWLQDIT NLRKVYSEAL SPSSTLQELD
LNSSLPTQDP IISGQKRRRY DLDEYLEEDK SSVVNDTIKA KDFDESVPAK IRKISVSKKT
LKSNW
//
