ID HXC8_CHICK Reviewed; 242 AA.
AC Q9YH13;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 119.
DE RecName: Full=Homeobox protein Hox-C8;
DE Short=cHoxc-8;
GN Name=HOXC8; Synonyms=HOXC-8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Skin;
RX PubMed=9389453;
RX DOI=10.1002/(sici)1097-0177(199711)210:3<274::aid-aja8>3.0.co;2-d;
RA Kanzler B., Prin F., Thelu J., Dhouailly D.;
RT "CHOXC-8 and CHOXD-13 expression in embryonic chick skin and cutaneous
RT appendage specification.";
RL Dev. Dyn. 210:274-287(1997).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Transcripts are present at 3.5 dpc in the somitic
CC cells, which give rise to the dorsal dermis by 5 dpc, and at 6.5 dpc to
CC 8.5 dpc in the dorsal dermal and epidermal cells during the first
CC stages of feather morphogenesis. {ECO:0000269|PubMed:9389453}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X94179; CAA63888.1; -; mRNA.
DR RefSeq; NP_990224.1; NM_204893.1.
DR AlphaFoldDB; Q9YH13; -.
DR SMR; Q9YH13; -.
DR STRING; 9031.ENSGALP00000050413; -.
DR Ensembl; ENSGALT00000082443; ENSGALP00000050413; ENSGALG00000037262.
DR Ensembl; ENSGALT00010062742.1; ENSGALP00010038783.1; ENSGALG00010025708.1.
DR GeneID; 395711; -.
DR KEGG; gga:395711; -.
DR CTD; 3224; -.
DR VEuPathDB; HostDB:geneid_395711; -.
DR GeneTree; ENSGT00940000161194; -.
DR InParanoid; Q9YH13; -.
DR OMA; PSIMFPW; -.
DR PhylomeDB; Q9YH13; -.
DR Reactome; R-GGA-9762293; Regulation of CDH11 gene transcription.
DR PRO; PR:Q9YH13; -.
DR Proteomes; UP000000539; Chromosome 34.
DR Bgee; ENSGALG00000037262; Expressed in ovary and 2 other cell types or tissues.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR46166; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46166:SF4; HOMEOBOX PROTEIN HOX-C8; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..242
FT /note="Homeobox protein Hox-C8"
FT /id="PRO_0000200183"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 112..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 138..143
FT /note="Antp-type hexapeptide"
FT COMPBIAS 112..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 27962 MW; A24DD9427A709FA3 CRC64;
MSSYFVNPLF SKYKGGESLE PTYYDCRFPQ SVSRSHALVY GPGTTAPTFQ HPSHHVQEFF
HHGTSSISNS GYQQNPCALA CHGDASKFYG YEALPRQSLY GAQQETTVVQ YPDCKSSSNS
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KTEEEGNEEE EKEEEEKEES
KD
//
