ID   I0DE44_HBV              Unreviewed;       671 AA.
AC   I0DE44;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AFH87875.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH87875.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFH87875.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=478-8782-5 {ECO:0000313|EMBL:AFH87875.1};
RX   PubMed=22293432; DOI=10.1093/infdis/jir862;
RG   NHLBI-REDS-II Study Group;
RA   Delwart E., Slikas E., Stramer S.L., Kamel H., Kessler D., Krysztof D.,
RA   Tobler L.H., Carrick D.M., Steele W., Todd D., Wright D.J., Kleinman S.H.,
RA   Busch M.P.;
RT   "Genetic diversity of recently acquired and prevalent HIV, hepatitis B
RT   virus, and hepatitis C virus infections in US blood donors.";
RL   J. Infect. Dis. 205:875-885(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN604302; AFH87875.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..576
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          200..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH87875.1"
FT   NON_TER         671
FT                   /evidence="ECO:0000313|EMBL:AFH87875.1"
SQ   SEQUENCE   671 AA;  75695 MW;  E010571EF089375A CRC64;
     LPRLADADLN RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS SSVPIFNPEW QTPSFPKIHL
     QEDIIDRCQQ FVGPLTVNEK RRLKLIMPAR FYPNHTKYLP LDKGIKPHYP DQVVNHYFQT
     RHYLHTLWKA GVLYKRESTR SASFCGSPYS WEQELHHGRL VINTSQRHGD ESFCSQPSGI
     LSRSSVGPCI RSQLKQSRLG LQPHQGPLAR SQPGRSGSIR ARAHPSTRQY FGVEPSGSGH
     IDHSVNSSSS CLHQSAVRKA AYSHLSTSQR QSSSGHAVEF HCLPPSSAGS QSQGSVFSCW
     WLQFRNSKPC SEYCLSHLVN LREDWGPCDE HGEHHIRIPR TPARVTGGVF LVDKNPHNTA
     ESRLVVDFSQ FSRGTTRVSW PKFAVPNLQS LTNLLSSNLS WLSLDVSAAF YHIPLHPAAM
     PHLLIGSSGL SRYVARLSSN SRINNNQYGN VQNLHDSCSR QLYVSLMLLY KTYGWKLHLY
     SHPVVLGFRK IPMGVGLSPF LLAQFTSAIC SVVRRAFPHC LVFSYMDDVV LGAKSAHHRE
     SLYTAVTNFL LSLGIHLNPN KTKRWGYSLN FMGYIIGSWG TLPQDHIVQK IKHCFRKLPV
     NRPIDWKVCQ RIVGLLGFAA PFTQCGYPAL MPLYACIQAK QAFTFSPTYK AFLRDQYMNL
     YPVARQRPGL C
//