ID I0DG45_HBV Unreviewed; 212 AA.
AC I0DG45;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=C {ECO:0000256|RuleBase:RU361253, ECO:0000313|EMBL:AFH89069.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH89069.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AFH89069.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bgeno45 {ECO:0000313|EMBL:AFH89069.1};
RA Desmond C.P., Gaudieri S., James I.R., Pfafferott K., Chopra A., Lau G.K.,
RA Audsley J., Day C., Chivers S., Gordon A., Revill P.A., Bowden S.,
RA Ayres A., Desmond P.V., Thompson A.J., Roberts S.K., Locarnini S.A.,
RA Mallal S.A., Lewin S.R.;
RT "Viral adaptation to host immune responses occurs in chronic hepatitis B
RT virus infection and adaptation is greatest in HBeAg negative disease.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; JQ341496; AFH89069.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 3.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT REGION 172..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..202
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 212
FT /evidence="ECO:0000313|EMBL:AFH89069.1"
SQ SEQUENCE 212 AA; 24326 MW; 4598BCC3B3DA119F CRC64;
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA SVELLSFLPS DFFPSIRDLL
DTASALYREA LESPEHCSPH HTALRQAILC WGELMNLATW VGSNLEDPAS RELVVSYVNV
NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPXAPILS TLPETTVVRR
RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC
//
