ID I0DGK0_HBV Unreviewed; 843 AA.
AC I0DGK0;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AFH89224.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH89224.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AFH89224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cgeno52 {ECO:0000313|EMBL:AFH89224.1};
RA Desmond C.P., Gaudieri S., James I.R., Pfafferott K., Chopra A., Lau G.K.,
RA Audsley J., Day C., Chivers S., Gordon A., Revill P.A., Bowden S.,
RA Ayres A., Desmond P.V., Thompson A.J., Roberts S.K., Locarnini S.A.,
RA Mallal S.A., Lewin S.R.;
RT "Viral adaptation to host immune responses occurs in chronic hepatitis B
RT virus infection and adaptation is greatest in HBeAg negative disease.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JQ341661; AFH89224.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 357..600
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 843
FT /evidence="ECO:0000313|EMBL:AFH89224.1"
SQ SEQUENCE 843 AA; 94604 MW; FBEBF197876D885B CRC64;
MPLSYQHFRK LLLLDDEAGP LEEELPRLAD EGLNRRVAED LNLGNLNVSI PWTHKVGNFT
GLYSSTVPIF NPDWQTPSFP HIHLKEDIIN RCQQYVGPLT VNEKRRLKLI MPARFYPNLT
KYLPLDKGIK PYYPEHIVNH YFQTRHYLHT LWKAGILYKR ETTRSASFCG SPYSWEQELQ
HGRLVFQTSK RHGDESCCSQ SSGILSRSPV GPCIQSQFKQ SRLGLQPQQG SMASGKPGRS
GILRARVHST SRXSFGVEPS GSRHIDNSTS SASSCLHQSA VRKTAYSHLS TSKRQSSSGH
AVELQHIPPS SARSQSEGPI LSCWWLQFRN SKPCSDYCLS HIVNLLEDWG PCTEYGEHHI
RIPRTPARVT GGVFLVNKNP HNTTESRLVV DFSQFSRGST HVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHLPLH PAAMPHLLVG SSGLPRYVAR LSSTSRNINY QHGTMQDLHD
SCSRNLYVSL LLLYKTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHLESLFTSI TNFLLSLGIH LNPNKTKRWG YSLNFMGYVI
GSWGTLPQEH IVQKIKQCFR KLPINRPIDW KVCQRIVGLL GFAAPFTQCG YPALMPLYAC
IQAKQAFTFS PTYKAFLCKQ YLNLYPVARQ RPGLCQVFAD ATPTGWGLAM GHQRMRGTFV
APLPIHTAEL LAACFARSRS GAKLIGTDNS VVLSRKYTSF PWLLGCAANW ILRGTSFVYV
PSALNPADDP SRGRLGLYRP LLRLPFRPTT GRTSLYAVSP SVPSHLPDRV HFASPLHVAW
RPP
//
