ID I0I001_CALAS Unreviewed; 874 AA.
AC I0I001;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:BAL98588.1};
GN OrderedLocusNames=CLDAP_05490 {ECO:0000313|EMBL:BAL98588.1};
OS Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 /
OS STL-6-O1).
OC Bacteria; Chloroflexota; Caldilineae; Caldilineales; Caldilineaceae;
OC Caldilinea.
OX NCBI_TaxID=926550 {ECO:0000313|EMBL:BAL98588.1, ECO:0000313|Proteomes:UP000007880};
RN [1] {ECO:0000313|EMBL:BAL98588.1, ECO:0000313|Proteomes:UP000007880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1
RC {ECO:0000313|Proteomes:UP000007880};
RA Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S.,
RA Hanada S., Yamazaki S., Fujita N.;
RT "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC
RT 102666).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; AP012337; BAL98588.1; -; Genomic_DNA.
DR RefSeq; WP_014431829.1; NC_017079.1.
DR AlphaFoldDB; I0I001; -.
DR STRING; 926550.CLDAP_05490; -.
DR KEGG; cap:CLDAP_05490; -.
DR PATRIC; fig|926550.5.peg.579; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_0; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000007880; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000007880}.
FT DOMAIN 696..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 622..629
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 874 AA; 97107 MW; C7EDD4D12E0A2571 CRC64;
MTTPMRQQYL SIKSQYPDCI LLFRLGDFYE TFDEDARIVA RVCDVVLTSR PVGADQRVPL
AGVPYHSVDY YIAKLVNAGY RVAIAEQVSE PGKGLVEREV RRVVTKGTLV DPGMLDERRN
NYLIAVVMGR RGATAGIAYC DISTGEFAAT QISAPSQEEV ERRIGEEISR LQPSELIHID
WEPQHSSLHG LIALHHPLLT TLEAWRVSLE TAEASLKRHF GVATLDGYGL QGKPEAIRAA
AAVLAYVGDM QPGACAQLTR LSTYTLDAFM TLDEATRRNL ELTETMRSGE VEGSLLGVLN
ATLTPMGSRL LRRWINQPLL DVAAINRRLD AVQRFVDDTL LRLDLRALLQ NFGDLERWTN
RVMQGIALPR DLVGIREALR LAPKVAERLG NWQRAHEDSG TTDFPLCADI LALLESALVD
DPPANLSTPG LIRPGFDAEL DSLVERSRHA REWIAGLEQV ERERLGIKNL KVGYNKVFGY
YIEVTKSQLD RVPNSYIRKQ TIANGERYIT PELKEYETLV LNADERRLEI EQRLFGEICA
QVAAQGTRLL HLAHLLAEID VFAALAEVAL TRRYVRPEVD EGPCIEIVAG RHPVVEMTLT
DEPFVPNDTL LTPETAIQII TGPNMSGKST YLRQTALITL MAQIGSFVPA ERARIGVVDR
IFTRLGASDE IHRGQSTFMV EMVETANILH HATPRSLLLL DEIGRGTSTY DGLAIAWAVI
EYIHNHPRLR AKTLFATHYH ELTDLAERLP HVVNYNVAVD DSGDGEDVVF LRRIIPGKAD
RSYGVHVARM AGLPAQVVAR AEEILADLER SGAAGPRRLA EAVAPKRRAG AVQVSLFADV
HPVVEALRKL DINNLTPLDA LNRLYELQKM AGEG
//
