ID   I0IFL3_PHYMF            Unreviewed;       659 AA.
AC   I0IFL3;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Transketolase {ECO:0000313|EMBL:BAM04051.1};
DE            EC=2.2.1.1 {ECO:0000313|EMBL:BAM04051.1};
GN   Name=tkt {ECO:0000313|EMBL:BAM04051.1};
GN   OrderedLocusNames=PSMK_18920 {ECO:0000313|EMBL:BAM04051.1};
OS   Phycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01).
OC   Bacteria; Planctomycetota; Phycisphaerae; Phycisphaerales;
OC   Phycisphaeraceae; Phycisphaera.
OX   NCBI_TaxID=1142394 {ECO:0000313|EMBL:BAM04051.1, ECO:0000313|Proteomes:UP000007881};
RN   [1] {ECO:0000313|EMBL:BAM04051.1, ECO:0000313|Proteomes:UP000007881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 102666 / KCTC 22515 / FYK2301M01
RC   {ECO:0000313|Proteomes:UP000007881};
RA   Ankai A., Hosoyama A., Terui Y., Sekine M., Fukai R., Kato Y., Nakamura S.,
RA   Yamada-Narita S., Kawakoshi A., Fukunaga Y., Yamazaki S., Fujita N.;
RT   "Complete genome sequence of Phycisphaera mikurensis NBRC 102666.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|ARBA:ARBA00007131}.
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DR   EMBL; AP012338; BAM04051.1; -; Genomic_DNA.
DR   RefSeq; WP_014437269.1; NC_017080.1.
DR   AlphaFoldDB; I0IFL3; -.
DR   STRING; 1142394.PSMK_18920; -.
DR   GeneID; 80848210; -.
DR   KEGG; phm:PSMK_18920; -.
DR   eggNOG; COG0021; Bacteria.
DR   HOGENOM; CLU_009227_3_1_0; -.
DR   OrthoDB; 9803371at2; -.
DR   Proteomes; UP000007881; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43195:SF1; FI06132P-RELATED; 1.
DR   PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007881};
KW   Transferase {ECO:0000313|EMBL:BAM04051.1}.
FT   DOMAIN          344..518
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   659 AA;  69316 MW;  02CC3BE4228A700E CRC64;
     MSFDSTIHDK AIQLTKLTYE ITGAAGSGHP SSGASLAHLV SVLLYQQMRF EPMNPGHPAS
     DRLVLSEGHA VPVLYAAMAD LGIAYRRFDG PDDAEGTLKP MTHELARTLR AIDSPVDGHP
     NPALGFPFFD AATGSLGQGL SVAAGLALAA RMDGLGKRIY CLIGDGESRE GQVWEAVDFL
     IDHGLKAVCP VFNANRFAQS EAVSVQQSAD VLVAKLEAAG FDVRDVDGHA PEAVAGAFSA
     HAQAQHNPDA APVALVARTV KGWGAQSQHG NGHHGTAPTG EALEAALAEL DAKHKQLGAT
     ADVKLQRDLL PPEKPGPVKR EQMPAFDEAC RSFGQEEVLA KGVLATRKAY GISLRALGHA
     RGDVAALDAD VSGSTGSASF KKDPELTGRF IECRIAEQNM VSAALGMAAG GKLPVVSTFG
     KFLTRAYDQV EMAVLSGQPL RLVGSHAGCT LGPDGPSQMA LPDVAWFRSF GTMRDHRGHP
     GFYVCTPADA WATHGLVAAM ADHPGSVYLR TMRPETEFLY GPGTTFTLGG HEVLNQGRDL
     LIVAQGYMVH QANAALEALD AQGVDATIVD LYSLPFDEEA LADLANDHDG RVLTLEDNYG
     GGMGSAVADA LAATGDGFTV KQMHVERLPK SGADADDILA YVGLSVDDVV REALGMLEL
//