ID   I0IX98_9HEPC            Unreviewed;       176 AA.
AC   I0IX98;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Polyprotein {ECO:0000313|EMBL:BAM09897.1};
DE   Flags: Fragment;
OS   Hepatitis C virus subtype 1b.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus hominis.
OX   NCBI_TaxID=31647 {ECO:0000313|EMBL:BAM09897.1};
RN   [1] {ECO:0000313|EMBL:BAM09897.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SS060217 {ECO:0000313|EMBL:BAM09897.1};
RA   Suzuki F., Sezaki H., Akuta N., Suzuki Y., Seko Y., Kawamura Y., Hosaka T.,
RA   Kobayashi M., Saito S., Arase Y., Ikeda K., Kobayashi M., Mineta R.,
RA   Watahiki S., Miyakawa Y., Kumada H.;
RT   "Prevalence of hepatitis C virus variants resistant to NS3 protease
RT   inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with
RT   genotype 1b.";
RL   J. Clin. Virol. 54:352-354(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; AB709505; BAM09897.1; -; Genomic_RNA.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR004109; HepC_NS3_protease.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   Pfam; PF02907; Peptidase_S29; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   DOMAIN          1..176
FT                   /note="Peptidase S29"
FT                   /evidence="ECO:0000259|PROSITE:PS51822"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAM09897.1"
FT   NON_TER         176
FT                   /evidence="ECO:0000313|EMBL:BAM09897.1"
SQ   SEQUENCE   176 AA;  18484 MW;  5C82912CD15FEBC3 CRC64;
     APITAYSQQT RGLLGCIITS LTGRDKNQVE GEVQVVSTAT QSFLATCVNG VLWTVFHGAG
     SKTLAGPKGP IIQMYTNVDQ DLIGWQAPPG ARSLTPCTCG SSDLYLVTRH ADVIPVRRRG
     DSRGSLLSPR PVSYLKGSSG GPLLCPSGHV VGVFRAAVCT RGVAKAVDFV PVESME
//