ID I0K3D2_9BACT Unreviewed; 1863 AA.
AC I0K3D2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Alpha-2-macroglobulin domain protein {ECO:0000313|EMBL:CCG98635.1};
GN ORFNames=FAES_0624 {ECO:0000313|EMBL:CCG98635.1};
OS Fibrella aestuarina BUZ 2.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Fibrella.
OX NCBI_TaxID=1166018 {ECO:0000313|EMBL:CCG98635.1, ECO:0000313|Proteomes:UP000011058};
RN [1] {ECO:0000313|EMBL:CCG98635.1, ECO:0000313|Proteomes:UP000011058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BUZ 2T {ECO:0000313|Proteomes:UP000011058};
RX PubMed=22689241; DOI=10.1128/JB.00550-12;
RA Filippini M., Qi W., Blom J., Goesmann A., Smits T.H., Bagheri H.C.;
RT "Genome Sequence of Fibrella aestuarina BUZ 2T, a Filamentous Marine
RT Bacterium.";
RL J. Bacteriol. 194:3555-3555(2012).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; HE796683; CCG98635.1; -; Genomic_DNA.
DR STRING; 1166018.FAES_0624; -.
DR KEGG; fae:FAES_0624; -.
DR PATRIC; fig|1166018.3.peg.634; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_000965_1_0_10; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000011058; Chromosome.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011058};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1863
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003630124"
FT DOMAIN 965..1103
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1166..1255
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1863 AA; 202468 MW; 445E5A26F98C6614 CRC64;
MRSPLFARLA LLRPALLLLT TTLLLTQCAR LSNTVQITGR NFDDEIQQSQ NLTFSFNKNV
GPENPTDVWE TTPYIEFKPA VKGQFKWVSP SELLFSPAVA FDPATDYRAE LTKAVLTRAD
SKDLSVSGDK VQFHTPYLQL TGTETWWTRQ TDNGQPVAKT RLRFNYAVSG AEVAPKLSLK
TGEQALTLGP LQGNADPLMG GGLVVTLPNA PRADNEQPLT LTVDKGLNVP NTAYTSKEII
EQTGTLPTPT RLEVVDVQTS YTRQQGVVRV VTTQTLQPGN LNQYYTIQPA IDTKAELTDN
GLLIRGDFNE TDTYVVTFTD AMRGVLGAKL TEPVARDVFF GKMPAGLQFA NRTALYLSSK
GARNVGLSIT NVDKVQVKIS RLYENNLLSY FKNGRYEEYA QQGDGEEAQW GPTGKYTYGN
DEEGDLSSVL IDKTITTTDL PKVRGVSALN LSIPEGAAGS NPDRPLRGAY LVSVQSKDEA
YVSATQLVSI SDIGLITRKT DNELLVWANS IQTAAPLSNV EITLISSNNQ SVYTLKTDSD
GFVRFEKVAE KAPGFKIAML TARTTSDANQ GDFNFLYLAD TQVETSRFEV DGKRSNPTGL
NAFVYGDRNI YRPGETIHLN TVLRGELPKT DVDALPLTLR VLMPNGAEYR SFRQTTNAQG
AVLTDVPIDP AAVTGSYTVE VLNANQTLLA SQAISVEEFI PDRIKVDVKT DRESYSAGQT
ITLQTTAQNL FGPPASDRAY EVELQLKRKN FAPKGYEQYH FNVPIEGTGV PATFEKTLRQ
GRTNANGQAT EAFPIPTEYR DIGLLEAKLF VTVFDENGRP VNRLRRLDIQ TQPIFYGIRL
ADTYLTTNTP LAVDVVALTN EGRPQAAKAQ VEVVRFDYQT VTEKQDNGQI KYSSKRREKI
VYTNILSLGG AASAGTFRYV PTVSGEYEVR VRRPNAVGYT SAEFYAYGWG STSASSFEVS
TEGQVLMEFD KPSYETGSTV KVLFKAPFNG KLLVTVERNS VLEQHWLETK DKAAEWSFSV
GDAHLPTAYV TATLIRAMDG TDLPLTVAHG FAPVTVTDPA TQLPVTIEAV AKSFSKTKQT
IRVKTKANAE VTVAVVDEGI LQLKNFKTPN PHGFFFQKRA LEVEAYDGYA LLYPELSLRS
RSSVGGDGYD LERRVNPLSN KRVQLVALWS GHLKTGSSGE AEYTIDIPQF SGTLRVMAVA
YKDNAFGSAE QGITVSDPIV ISAGVPRFLS PGDELNMPVN LSNTTSQAAG VTASVTVSGP
LQVVADSAVR RGAGTAQSLT VQPGRESRTA FRIRATGGVG PGDITITVKA MGKTFVEKTD
ITVRPAAPLQ RTTISGAVAG GRSATLSLTG DFVPGTTRNS LTISRSPVTQ YAKTLSYLLG
YPHGCTEQTI SKAFPQLYFA DLTKSVRQGT VYFVRTGDSD YNPATNIQQA LQQIESRQLY
NGGISLWPGF TLEDSWTTAY ALHFMVEAQK AGYEVSAGVK SKIVDRLTTL TGTNRTVTQS
VFAEDGTRTD RPVASYTNLY ALYALALAEQ PNRAAMSFYK EATNTLLTTD GRYLLATTYA
RLGDAQSSAA LLPKQFTSTT SGRETGDSYS SPVRNMALVL SNLIDTDPDN LQIPTLARQL
GGAVQQATYL NTQEAAFAFL ALGKLARQTA GSTATATLTA AGKGLLGTFA GDDLTLRRLP
TGKPLTLSAK GSGSVYYFGQ SEGVPSQGIV ADEDAGLVVR RTYLSRDGSP LSRFRQNDLI
VVKLTLGSQN GLPVKNIVLT DLLPAGFEVE NPRLTGDQST GGAQSGSVRT LSWLKGAATV
DHFDIRDDRV NYYLSLTGTE TKTVYYMVRA VTKGRFVVGP VSADAMYNPE LRSYNGAGRV
TVE
//
