ID I0QGJ7_STRSL Unreviewed; 741 AA.
AC I0QGJ7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=cellulose synthase (UDP-forming) {ECO:0000256|ARBA:ARBA00012539};
DE EC=2.4.1.12 {ECO:0000256|ARBA:ARBA00012539};
GN ORFNames=PS4_40421 {ECO:0000313|EMBL:EIC80407.1};
OS Streptococcus salivarius PS4.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1157946 {ECO:0000313|EMBL:EIC80407.1, ECO:0000313|Proteomes:UP000010314};
RN [1] {ECO:0000313|EMBL:EIC80407.1, ECO:0000313|Proteomes:UP000010314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PS4 {ECO:0000313|EMBL:EIC80407.1,
RC ECO:0000313|Proteomes:UP000010314};
RX PubMed=22843595; DOI=10.1128/JB.00896-12;
RA Martin V., Maldonado-Barragan A., Jimenez E., Ruas-Madiedo P.,
RA Fernandez L., Rodriguez J.M.;
RT "Complete Genome Sequence of Streptococcus salivarius PS4, a Strain
RT Isolated from Human Milk.";
RL J. Bacteriol. 194:4466-4467(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIC80407.1}.
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DR EMBL; AJFW01000054; EIC80407.1; -; Genomic_DNA.
DR AlphaFoldDB; I0QGJ7; -.
DR PATRIC; fig|1157946.4.peg.1860; -.
DR Proteomes; UP000010314; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035438; F:cyclic-di-GMP binding; IEA:InterPro.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06421; CESA_CelA_like; 1.
DR Gene3D; 2.40.10.220; predicted glycosyltransferase like domains; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR009875; PilZ_domain.
DR PANTHER; PTHR43867; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR PANTHER; PTHR43867:SF2; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR Pfam; PF13632; Glyco_trans_2_3; 1.
DR Pfam; PF07238; PilZ; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF141371; PilZ domain-like; 1.
PE 4: Predicted;
KW Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EIC80407.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..384
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF13632"
FT DOMAIN 509..606
FT /note="PilZ"
FT /evidence="ECO:0000259|Pfam:PF07238"
SQ SEQUENCE 741 AA; 86234 MW; AD3A22E8501A7C75 CRC64;
MKTSKRILYF VAFVTTAFYL TWRLVATIPW HDSWFALIFG ILLWGSEVVS AITGYILIWN
KQKDFELEKP EIAKERYPDV DVLIATHNED PELLYKTINA CTFMEYPDKS KVHIYVCDDT
NRLEVAKLAD ELGVGYFGLA DNKDAKSGNY NNALRQTSSP LVATFDADMI PYREFLLETV
PYFVEQVEAY ENGDDYDKSK VGLIQTPQSF YNADIFQFNL FSESTLPNEQ DFFSKEINVF
NNSHGAALYT GSNTLIFRKA IEDVGGFPTD TITEDFELGV RINAAGYVNY STKSPMASGL
TPTDLKSVIK QRVRWGRGVI RSSYNMNIFF NPKLTMGQRI VYINGYLYWW SFFRRLLFIL
APILYTVFHV RVVVSNIWLL FLFWLPSFAL TRLSMREVSK QYQTQVWGEI VETIFAPYLF
IPMMLESFGI SNTKFKVTRK GNYTSWTLYL YAIPYLVLWV LAVYGLVTFN YGKFGSELFY
GSIISFWLIY HIINLTFAIF CALGRPIYRS SERFTVDEAM VIEVDDDSYQ VRVCDISETG
ISFYTDLPLY LPKEKELTLN LQSRDYHARV KGHVVRVFAI DNGWCYGVQF SEVPEADKRE
FYQYIYDRIN HNLPKKKDPW MTTWDDLFEN FSQRFQNNER PVSAYDQVAF PKVRANEEVQ
VAGKKCQLRK TDYYYMTFSG KLTNPKKEPN VAFTYKDLPI QLTFVSYDTD RDESLYRVTN
LADLDSLPAF KALANEWRGR V
//
