ID I0Z681_COCSC Unreviewed; 504 AA.
AC I0Z681;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00012247};
DE EC=3.1.4.46 {ECO:0000256|ARBA:ARBA00012247};
GN ORFNames=COCSUDRAFT_46517 {ECO:0000313|EMBL:EIE26150.1};
OS Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Trebouxiophyceae incertae sedis; Elliptochloris clade; Coccomyxa;
OC Coccomyxa subellipsoidea.
OX NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE26150.1, ECO:0000313|Proteomes:UP000007264};
RN [1] {ECO:0000313|EMBL:EIE26150.1, ECO:0000313|Proteomes:UP000007264}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-169 {ECO:0000313|EMBL:EIE26150.1,
RC ECO:0000313|Proteomes:UP000007264};
RX PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J., Proschold T.,
RA Salamov A., Schmutz J., Weeks D., Yamada T., Claverie J.M., Grigoriev I.,
RA Van Etten J., Lomsadze A., Borodovsky M.;
RT "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT reveals traits of cold adaptation.";
RL Genome Biol. 13:R39-R39(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-
CC glycerol 3-phosphate; Xref=Rhea:RHEA:12969, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:57597,
CC ChEBI:CHEBI:83408; EC=3.1.4.46;
CC Evidence={ECO:0000256|ARBA:ARBA00029315};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE26150.1}.
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DR EMBL; AGSI01000003; EIE26150.1; -; Genomic_DNA.
DR RefSeq; XP_005650694.1; XM_005650637.1.
DR AlphaFoldDB; I0Z681; -.
DR STRING; 574566.I0Z681; -.
DR GeneID; 17044154; -.
DR KEGG; csl:COCSUDRAFT_46517; -.
DR eggNOG; KOG2258; Eukaryota.
DR OrthoDB; 5477293at2759; -.
DR Proteomes; UP000007264; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR43620:SF7; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD6; 1.
DR PANTHER; PTHR43620; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 2.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 4: Predicted;
KW Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007264};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..504
FT /note="glycerophosphodiester phosphodiesterase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003637533"
FT TRANSMEM 400..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..375
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 504 AA; 54420 MW; 143B98D33447C389 CRC64;
MLKFQCSTLS AALVCAVCVL HLAFTASADE HKAPLIIAHR GSPCHFPEET LEGFSRAIEY
GVDYIEMDVV STKDGHLICR HELTLDDSTD VADHPEFAER KWATTLPSGR EQSGFFAANF
TLQEIRTLYA RQAIPFRNQA SSHSFRVRTL PEVLQLAMNS TESGRPVGVY IETKGPAFHS
SIGQPLEARL VDALIAAGYG KMAAAPLILQ SFELQSLQNL SRELEARGLP GRADLVWLLD
CASEVNDTQL DAFATYGYGI GPEKSMVATL DLAPECARSE GDACSAVSPS QTCTGRLTTA
AAAGAAARSG ATVRSGLVER AHARGLVVHP YTFRNEGRFM ALDFDADPLA ELSLFRELGV
DGVFVDCPAT AAEWLATQHL TPTSWIGSVI GGPGPRQSAA IASVSVLATL LAITLVWGVV
TLVRHRRRQR AKYDFFPSMF NTGDLTWYPP DYRRAVVDEA GGGSRGEECG EDTPLPTSIM
MTTIDSPPRI AERERRADNA AGGT
//
