ID I0ZA76_COCSC Unreviewed; 1910 AA.
AC I0ZA76;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=PX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCSUDRAFT_55543 {ECO:0000313|EMBL:EIE27545.1};
OS Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Trebouxiophyceae incertae sedis; Elliptochloris clade; Coccomyxa;
OC Coccomyxa subellipsoidea.
OX NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE27545.1, ECO:0000313|Proteomes:UP000007264};
RN [1] {ECO:0000313|EMBL:EIE27545.1, ECO:0000313|Proteomes:UP000007264}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-169 {ECO:0000313|EMBL:EIE27545.1,
RC ECO:0000313|Proteomes:UP000007264};
RX PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J., Proschold T.,
RA Salamov A., Schmutz J., Weeks D., Yamada T., Claverie J.M., Grigoriev I.,
RA Van Etten J., Lomsadze A., Borodovsky M.;
RT "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT reveals traits of cold adaptation.";
RL Genome Biol. 13:R39-R39(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE27545.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGSI01000001; EIE27545.1; -; Genomic_DNA.
DR RefSeq; XP_005652089.1; XM_005652032.1.
DR STRING; 574566.I0ZA76; -.
DR GeneID; 17045560; -.
DR KEGG; csl:COCSUDRAFT_55543; -.
DR eggNOG; KOG1829; Eukaryota.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000007264; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd06093; PX_domain; 1.
DR CDD; cd17671; RUN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007264};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 563..706
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1519..1641
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 116..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1910 AA; 199203 MW; A8AC1EF9B3745392 CRC64;
MERAFPVLMS PGVDAVRSQE AVGLEAVSRL WIQQGAQDGS LGFLVSKVRS QPQVYTAYLN
SAPMRSKEAT AEFEAAVLPL KGTVTFAELQ AAIASSKASA GSAASGTDAA TIEARDAAPH
VAPPKQPSPA RQDQESASGS DTDTAQPASA RLGQLWEAQW SRLPMGQAAS SAPHGADANM
AETEGPMKAH APGRRHPMGD AGHISVSMSA PEAANAARQH VSQPDSVAVR LEIQEASDGG
GAFVTLHLDT RGSDQAGKGL QQPSRQSRLA QQFDQVMQSQ ASAAALSGMQ SLAGLLKGPK
WTRQGPPIPT AAPSSQEESA AEAAQDKEGA DRAITSSLAS DAAVQEDAPA KLVVVQISAS
EAGAEHEAII QPCRVTLRIL GDASTAAAVP IPSAPGSAPH GRLGAFSGLF RSSKGGSQTP
VTDPGSILPL REVAAETTDP EIPAAQSLAG ADPQATSTTS DTALAGQRQN PAWAVAGAFG
SLYGFVSHAA DSAVRPGQQA GSKEAHAASS NRGPEASTSS RASAKPQGSR SPRALPTPSK
QEEEEAAAAE ELAGVGPAAD IMGPGDTDLQ RVCSGVEALL KHGLRPATPR DKWTQYLPGR
RTGPMDMLQE AQRLATVEEG KGWGLEGVEA LAGGHGSEAA LQMWIRSSLN ERALGSRLRA
LCSTPTLLQA WYSRSAVLRQ EEAAGQLLGV LMGLDAVKVL LPVETDSVKQ PTSGPVGFLA
GVTNFLPGRY STAAASPSVK GPALPPMTSS PKMRKRTRAV TIDEALQEPR PSAAAAAAAA
ADRSPAASEL LPSSLGALLL SPMSSADISA EPLSPTTTAA FQALRARHLA GVNMQASPED
RAAESDLLAH LLQQAGLSSE AALAPDLAGL HSRDYPGEPG VSLNGTGEAG ALEEPRPDLA
AFLDDLLSTP EDSMFAPQLG GEPLQFAGDP GKDPPPWQPL KPQSRGNTIA EAPSTSRDAG
PAAAGSPLLA AQEVASYNSA EERRKASEAA AAASERVRSR LARRRVTTSD ASEPQTPPAA
EPWRQQEDVS ALSTAGSTST MLGARSQEGD FYRLLDSEEP APRRSFHLDK NEQLPRSFSI
AARGEQLQAS NVTEQEAAEA VEAVLESEIA AQEETHPHDR DAQDSDADAS PSTSVEAPNA
LKPETPPEDL VETAHAHGEY EQQLTADPVH HASVHKILED QPSEDEAIAS AAEQNPEDHT
AAIPSHELPA AAQPALARQE PSAELSYSDL TSLLSTPEGD AQPVEAPSSG AEEAWPAEHS
SADDSPAPLP KADLAQLAFG QAGPSKVGGE AAEDSGAGRQ PPLPQPNPPP EPHGGEAQPA
EGTRGGASSA STAADKPSLQ PEQDVSPPHS QPEDTQKPAE VAHSEPLQDP AHLTPHTGVR
GVAGAAGTAE QTPGRQPTEQ QQAEIREFLA SQGLHNILDG QQMDMPELQG EDIADQLSPR
EHGSQTDANL LEDMNEILML DLGGLGGFRS PLGSPPRAGS SHFSFDDPHH PPRPPDLEPL
PPSWRIAEAR PTKAPFVLFM QIARVVGAAT VAEGTAEYTR YSVEVTPSDE GEAWTVHHRF
KDFIALRSAL TALVGPNSLP QCWADVSKAR SVTGRHRLAP EVVAARQAML DRCLVSVVAA
GPPLSEAPPL LAFLAPADPH WDPPSQPPGT LARALPGRGQ DAGAAAAQLA RAGSEHASSA
SSSAEAGNRY GSLVRLLTEE PQKLAEADLI RMQRGQCAAC RAPLPPPVKQ SSFLGGRSAA
TGPRRCEYNA RLYCHECHRG DLAELPALVL HHWDFHPRPV STMAADYLAS IADRPLLCIG
AVNPGLYARV PMLARAQDLR TRACKALAAA RASGPEGADK AKRLLAGAGP RRYLLESPDF
WAMRELVELS KGAFSRLPAW LEAAAARAAS LATSALLIAA AEQQQRPGRH
//
