ID   I0ZGF7_HELPX            Unreviewed;       340 AA.
AC   I0ZGF7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Sialic acid synthase {ECO:0000313|EMBL:EIE29726.1};
GN   ORFNames=HP17_08384 {ECO:0000313|EMBL:EIE29726.1};
OS   Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=102618 {ECO:0000313|EMBL:EIE29726.1, ECO:0000313|Proteomes:UP000004458};
RN   [1] {ECO:0000313|EMBL:EIE29726.1, ECO:0000313|Proteomes:UP000004458}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17874 {ECO:0000313|Proteomes:UP000004458};
RX   PubMed=22493206; DOI=10.1128/JB.00230-12;
RA   Clancy C.D., Forde B.M., Moore S.A., O'Toole P.W.;
RT   "Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79.";
RL   J. Bacteriol. 194:2402-2402(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIE29726.1}.
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DR   EMBL; AIHX01000065; EIE29726.1; -; Genomic_DNA.
DR   RefSeq; WP_000941799.1; NZ_AIHX01000065.1.
DR   AlphaFoldDB; I0ZGF7; -.
DR   PATRIC; fig|102618.3.peg.547; -.
DR   Proteomes; UP000004458; Unassembled WGS sequence.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR   CDD; cd11615; SAF_NeuB_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR   InterPro; IPR006190; AFP_Neu5c_C.
DR   InterPro; IPR036732; AFP_Neu5c_C_sf.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013132; Neu5Ac_N.
DR   InterPro; IPR020030; Pseudaminic_synth_PseI.
DR   InterPro; IPR013974; SAF.
DR   NCBIfam; TIGR03586; PseI; 1.
DR   PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR   PANTHER; PTHR42966:SF2; PSEUDAMINIC ACID SYNTHASE; 1.
DR   Pfam; PF03102; NeuB; 1.
DR   Pfam; PF08666; SAF; 1.
DR   SMART; SM00858; SAF; 1.
DR   SUPFAM; SSF51269; AFP III-like domain; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50844; AFP_LIKE; 1.
PE   4: Predicted;
FT   DOMAIN          281..339
FT                   /note="AFP-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50844"
SQ   SEQUENCE   340 AA;  37789 MW;  8B7A08211C83FEC4 CRC64;
     MLQRPKIVAE LSANHNQDLN LAKESLHAIK ESGADFVKLQ TYTPSCMTLD SKEDPFIIQG
     TLWDKENLYG LYQKASTPLE WHAELFELAR KLDLGIFSSP FSSKALELLE SLNCPMYKIA
     SFEIVDLDLI EKAARTQKPI ILSSGIATHA ELQDAISLCK GVGNFDITLL KCVSAYPSKI
     EDANLLSMVK LGETFGVKFG LSDHTIGSLC PILATTLGAS MIEKHFILNK SLQTPDSTFS
     MDFNEFKSMV GAIKQSVLAL GEEEPKINPK TLEERRFFVR SLFVIKDIQK GETLTSDNIK
     ALRPNLGLHP KFYKEILGQK ASKFLKANTP LSADDIERSL
//