ID I0ZGZ7_HELPX Unreviewed; 529 AA.
AC I0ZGZ7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Ribonuclease Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000256|HAMAP-Rule:MF_00335};
GN ORFNames=HP17_07977 {ECO:0000313|EMBL:EIE29916.1};
OS Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=102618 {ECO:0000313|EMBL:EIE29916.1, ECO:0000313|Proteomes:UP000004458};
RN [1] {ECO:0000313|EMBL:EIE29916.1, ECO:0000313|Proteomes:UP000004458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17874 {ECO:0000313|Proteomes:UP000004458};
RX PubMed=22493206; DOI=10.1128/JB.00230-12;
RA Clancy C.D., Forde B.M., Moore S.A., O'Toole P.W.;
RT "Draft Genome Sequences of Helicobacter pylori Strains 17874 and P79.";
RL J. Bacteriol. 194:2402-2402(2012).
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000256|HAMAP-
CC Rule:MF_00335}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE29916.1}.
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DR EMBL; AIHX01000054; EIE29916.1; -; Genomic_DNA.
DR AlphaFoldDB; I0ZGZ7; -.
DR PATRIC; fig|102618.3.peg.451; -.
DR Proteomes; UP000004458; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR CDD; cd22431; KH-I_RNaseY; 1.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR NCBIfam; TIGR00277; HDIG; 1.
DR NCBIfam; TIGR03319; RNase_Y; 1.
DR PANTHER; PTHR12826; RIBONUCLEASE Y; 1.
DR PANTHER; PTHR12826:SF15; RIBONUCLEASE Y; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_00335}; Coiled coil {ECO:0000256|SAM:Coils};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00335};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00335};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00335};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00335}; Transmembrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00335}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00335"
FT DOMAIN 342..435
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT COILED 101..190
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 529 AA; 60132 MW; 3889F7BA0915E89B CRC64;
MSSGLIYISL EVLVACLITA LVMYYVMKKI YYARGQAALK SASAKAKLME FQAKSFVEAE
EMRMKSQECK LQQQYENKNL QLQTHFDKKE AHLKHLEAQH KEFVRDEKRY LEKEKKELEK
ERQILEQERE NFKKQRAICK EAQAKALDAM LNYMAYTKDE IKSMILEQLE EELEAQKSAL
IKRYEKEAKE ESKKKSYAIL AEATARFAGN YATENLTSRI ALPCSDYIGR VIGKDGKNIE
AFKKVSGVDI EFSEDSSELC LSSFNLYRRE VASEALKILI EDGRIQPNRI EEVYHRVARN
LEKELLSEGE SVVLELELGA MEDELKILIG KMRYRSSFGQ NALQHSKEVA LLAGLIAEQL
GGDKKLARRA GILHDIGKAL TQELGRDHVN LGVEVCKRHK EDPVVINAIY AHHGHEEILS
VECASVCAAD ALSAGRPGAR RKSDEEYAKR MQALEEIALE FDGVEKAYAM ESGRELRVIV
KSNQVRDNQV PIIARKIAKK IEESAQYVGE VGVQVVRESR FKTTATLKQ
//
