ID   I1BHV2_RHIO9            Unreviewed;       963 AA.
AC   I1BHV2;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN   ORFNames=RO3G_00486 {ECO:0000313|EMBL:EIE75782.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE75782.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE75782.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476732; EIE75782.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1BHV2; -.
DR   STRING; 246409.I1BHV2; -.
DR   VEuPathDB; FungiDB:RO3G_00486; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   InParanoid; I1BHV2; -.
DR   OMA; WIEYHIE; -.
DR   OrthoDB; 1368294at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT   DOMAIN          807..963
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          59..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          691..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   963 AA;  108661 MW;  19D3DC5BC5EC9CFE CRC64;
     MNKETFSKRC FKCNAPFTRE HLNVCPKRNQ PLSAGSASSS STAPTITRAF RSLQLTGSED
     VPMGTKASKY NPANQQDHDE EQDLDDEAVK DIHYYSSLCK LQPFNTKLHS FNNKRTDSFF
     VPITIENVCT WALVDTGCNT STISPDLAKI INVRTFPVSG KLQLASLDAL VPRTAITDQI
     KVFYNGINVL HKFEIFKFDK DIPICIGTDL MPKLNVNLTG LAVTWDSPNI SAIPDPIDPS
     PIKPNKSPAG THQQREQLMN ALQPYLSANA KIPSTSACPL PEAIVRLETE PGKTTYRRQY
     PIALSIQPKV QEQVDKWLAD GVIEIAPPNT AFNSPLLTVR KKDANAELHQ KMSAATLFTV
     LDLKQAFHRL PLAEEHRALT AFTFNGQQYQ FCRAPFGLTP IPNHFQRVLT TLLHDLPYVT
     CFIDDLTIGT GPDIEEHIKC ITTVIERLTS AKFILNVDKC HFMQTSVNIL GFTISHNSLS
     LDSRKVANAL AWLIPKTGKD IQRFLGLANY FRSHLPNFST MTAPLGKLRN EGSLEHIWTD
     KYLQAFRNIQ TALSNAPVLS IPDMHHELQL ATDASNTGIG GVLYQIIDDK TRYIGFAARA
     LSKSEMNYST TKRELLAICY LFERFHKWLY GSHFTLYTDH KSLVYLGTQS IPNPMMLNWF
     ETIFNYTFRV IHRPGIENVL PDSLSRLFSD DTEKRLGGDS NPQQLSIKNK NTKSQNKRTT
     ENSTNIKQRA VQLVDYMTPP EEERHNLLLK AHLLGHFGAD AIVKTIHNDN LHWINIKKDA
     LQLVSNCPEC QQFNIGKHGY HPPRSILPDG PFDHVCIDLG TLNVTSTEGH NFILVLVDLF
     TRFTILRPLM DKTAVSIANE LRDIFCTFGW SKKLSSDNGT EFTNEIFNSL METCGIDHRL
     SLPYNPLGNS TNESFVGIAK RALAKRLQGK KDEWNLFLPS IQYAMNCKYY PCMKSINRVQ
     FSY
//