ID I1BZ95_RHIO9 Unreviewed; 4664 AA.
AC I1BZ95;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=RO3G_06230 {ECO:0000313|EMBL:EIE81525.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE81525.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE81525.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; CH476735; EIE81525.1; -; Genomic_DNA.
DR STRING; 246409.I1BZ95; -.
DR VEuPathDB; FungiDB:RO3G_06230; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; I1BZ95; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 1935..2073
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2239..2430
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2622..2772
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2964..3130
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 954..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3226..3288
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4664 AA; 534659 MW; A8CC223F5F32FC35 CRC64;
MLEDETTLNP ASSIAAPAAS EVLLVFDYQK LQEYFELLLP LVLGADVSDL ENTLFSYPDT
AEKFKRFAND PQTPVIFILK ERDNVKDEDD ATPATYSYTV SHEITYLPSH VGSLAVIKRS
ATLDQSRPLQ NQLQLINLPG APNAGEPGQT SAYEFLHSYI HLAVSPYFDA YVNARYGKTA
NETSSKSKNE DNKMGVPMAK KKMAELELSL LHLQQNVEIP EISLNIHPVV QRAVDKCREQ
NKRVTVEAVD STLFSDSSFL NKLQSDVNGW IKEIQKVTKM SRDPASGTAI QEINFWLSME
SALEKIDEQL KSDQITLTLD ILKHAKRFHA TVSFIADTGL KEGMERVHKY NQLMKDFPLN
ELLSATDLDK IRESLHMIFG HLNKKLKLSP YPIRRALPLV EAISKDLNDQ LLKVLGSRRM
MYMEYDDFER TTSGAESVFH TWDDLIKEFT NVARDVTRKR SEKFLPIKIN PAHAKLQERV
NFVRAFRKQH EQLHQTIVRV MTSPRAKKAT VVVDGQVKSV VEEEESVSIS DVNAVEEGTE
IWVQAEAAYN ERVSRVENQI IARLRDRLGT AKSANEMFRV FSKFNALFVR PKIRGAIQEY
QTQLIDSVKD DINKLHDKFK MQYRNSEAYH MAQLRDLPPI SGAIIWARQI DRQLSLYMKR
VEDVLGKGWE LYAEGQKLQI ESSSFRKKLD TRLIYENWLQ EITKRDLSVS GRIFEISRNR
VQKNALQLGV NFDGQIIALF KEVRNLLWLN FQVPHTISNV AKDAKRVYPF AVSLMETVRT
FSQTVHKVNR NPEISTLVAG YRNEVHNMIT KGINLRWDYF VNTYDAHHRP LSYLTGTPLD
ARENRHVMFV REFANVVSVF QDKVDDLIGY YDDITKGVDE MKACPYQAEK FEDTLGRIQK
IIDRLNLENY SNLDQWVAGL DKRIETVLIS RLQQAIKAWT NTFLGINEEA VMPEPSMSKS
RRKRKTGAHR DSIAPVEETA IQKNSDVKPA LQVLVHEVRI RNQVMYLDPP IEQARTSWWF
QLHDWLAVVC HLPRIQSSRY EGGLSVKDNP TVEKTYASLL TRMGDNSLEY AYQIVEDKIR
QVSDYVNIWL QYQSLWDLES SHVFSILEDD LGKWQQILLE IKKARATFDN SETEQSFGPL
VIDYEQVQSK VNQKYDQWQR EILNKFGSLL GTSVKDFHTS VSKARYELEQ QSIESNSTGE
AVTFITFVQD LKRKVAKWTL DVELFRQGQK TLERQRFQFP ADWVYVDQVD GEWSAFNEIL
SRKNNAIQEQ VAGLQMKIVA EDKVVEQKIR DICAEWEKTK PVQGDIKPDI ATNTLSIFEG
RVTRLKEEYD MVCRAKEALD LEQTSEARLD PVLEELRDLK SVWTALARVW QSLNEIRDTP
WSSVVPRKVR QSIDELVNST KEMPNRMRQY AAYEYMQDTL RQLLRVNPLV GDLKSEALRE
RHWRQIFKSL RVENRFTLSE MTIGHLWDLD LKRNEAVVRD VIMQAQGEMA LEEFLKQIKE
TWTGYVLDLV NYQNRCRLIR GWDDLFSKSS EHLNSLTAMK LSPYYKVFEE DASSWEDKLN
RIHVLFDVWI DVQRQWVYLE GIFSGSVDIK HLLPVETQRF QSINTEFLTV MKKVYKSPFV
LDVLNIPNIQ KSLERLAELL SKIQKALGEY LERERSSFPR FYFVGDEDLL EIIGNSKDIL
RIQKHFKKMF AGISNILLDE EQTSIIGMAS KEGEEVKFKT PVSIKDNPKI NDWLTLLENE
MRVSLAQLLT DAVTELENIY NAEEMSSPDF MEWIDRYPAQ LVVLAAQIIW TQSVDKALTT
IDEAGDSDQA PMQHAVGLIE RNLNILADAV LLDLKVIKRR KCEHLVTELV HQRDVTRQLV
ADNILSPRDF NWLYHMRFYF NHSVENPIHR LTINMANAQF YYGYEYLGVV DRLVQTPLTD
RCYLTLTQAL EQRLGGSPFG PAGTGKTESV KALGVQLGRF VLVFCCDETF DFQAMGRIFI
GLCQVGAWGC FDEFNRLEER ILSAVSQQVQ TIQLGLKEAT KNPNHEIELV GRNVRVNTDT
GIFITMNPGY AGRSNLPDNL KKLFRSMAMT KPDRELIAQV MLYSQGFRTA EILASKVVPL
FNLCAEQLSP QSHYDFGLRA LKSVLVSAGN LKRDRLTLLR EDIEKGEADQ TEYAKISEPV
PEQQLLISSI RETVEPKLVA DDIPLLTSLL ADVFPGVHYA PVNLDRLKEE LRKVCEERRF
VPGDAWMDKV IQLYQIQNIH HGLMMVGPSG AGKSTAWKTL LTALERVEGV EGIAYTIDPK
AIPKDALYGT LDSTTREWTD GLFTHILRKI VDNVRGESQK RHWIIFDGDV DPEWVENLNS
VLDDNRLLTL PNGERLNLPP NVRIMFEVET LKYATLATVS RCGMVWFSED IITLPMIFTN
YLETLRNVPM DEIEEEGSTS RRRTESGAAN GNGAAATEDG VSPNLHTQRA IADAMAPDLS
DEHCLVAKCL EYASTLEHIM DFTRMRVLST FFSLLNKTVR NVLEYNSQHP DFPMTGDHLE
GYINKRIIYS IIWSFSGDAK LDLRAVLGDF VRGVTTYELP PLTEGHTIID YDISVANGQW
VPWESKVPVI EIETHKVSDA DMIIPTVDTI RHEEVLYSWL SEHKPLILCG PPGSGKTMTL
FSALRKLPDM EVVGLNFSSA TNPELVLKTF EQHCEYRKTP NGVVLSPLNI GRWLVVFCDE
INLPATDKYH TQRVISFLRQ LVEYNGFWRT SDKSWVTLER IQFVGACNPP TDPGRVPLSH
RFLRHAPLVM VDYAGQLSLM QIYGTFTRAM LKVVPNLRGY AESLTGAMVE LYLASQKRFT
PDIQAHYIYS PRELTRWIRG IYEAIKPLET LTVEGLVRIW AHEALRLFQD RLVNEEERKW
TDDMIDSIAN KHFPSINHEE ALERPILFSN WLSKHYVPVK REQLRDFAKA RLKVFYEEEL
DVALVLFNDV LEHVLRIDRV FRQPQGHLLL IGVSGSGKTT LSRFVAWMNG LSVFQVKVHN
KYTGADFDDD LRTVLRRSGC KGEKICFIMD ESNVLDSGFL ERMNTLLANA EVPGLFEGDE
YASLMTACKE GAQRDGLMLD SNEELYKWFT QQVMRNLHVV FTMNPPEGGL ASRAATSPAL
FNRCVLDWFG DWPDQAFYQV GMEFTKTLDL DMPNYAAPLN FPITYRNLPI PPSHREAVVN
ALVYVHQSLY EINAKLSKRQ GRHNYATPRH FLDFISHYVR LYNEKREDLE EQQRHLNVGL
EKLKDTVIKV EELRKSLAIK KSQLELKQNQ ANEKIKQMVE DEKEAERKKA DSLIIKNNLK
IQTKEIEARR IEVDNDLANA EPAVKEAEMS VRSIKRQHLT EVRSMSNPPE AVKLTMESVC
TMLGHKIDSW KTVQGIIRRD DFISSIVNYD TEAQITKQLR DYMNKNFLNN PNFDYDMVNR
ASKACGPLYK WVTAQCNFSS ILDRVGPLRE ELNQLQRSSE DTQQQAVEMD KVISDLEVSI
RRYRDEYAEL VGETQIIKAE MERVKFKVDR SITLLSSLSS EKVRWESASQ AFESQMGTIV
GDVLLAAAFM AYGGYFDQQY RDILIQKWMD HLLTANIQFK HEVSLTEYLS SADDRLSWQA
NSLPADQLCI ENAIMLKRYD RYPLIIDPSG QATNFLINEY KDRKITVTSF LDDSFIKNLE
SALRFGNPIL IQDVEHLDPI LNPVLNKELR RTGGRVLIRL GSQDIDFSPA FTLFLSTRDP
SVNFAPDICS RVTFVNFTVT RGSLQSQCLN KVLKTERPDV DQKRTDLIKL QGEFQLKLRH
LEKSLLQALN ESKGNILDDD KVIDTLETLK KEAAEITSKV DETNTIMQEV EQTTAIYTPL
ANACSSIFFA MEQLNLVNHF YQFSLDFFYE IFEYVIHANP NLKGITDPDR RLEILSGDLF
SAAYKRASRS LNHEDYPMYA VLLCQIRMRG TQENMDETEF DFLLSGGEGV VSSNVTAESL
NLPSFISDDT ARRIKEFANL NCFNQLVNHV TTNEGVWKEF MEHNQPETIV PLCWDGAGSN
PILDSLRKML TVKCFRPDRL LPATNIFAAE IFDGEFMNTG ELNLQQIVLE EVGSSTPLAL
CSVPGYDASY RVDNLVSETN NRCTSVAMGS AEGFGLADQA ISAAIKTGTW VMLKNVHLAP
SWLGQLEKKL HSMKPHRNFR LFLTMETNPK VPVNLLRSLR SIPPSSLSRG PTERARLYFM
LAWLHAVVQE RLRYVPLGWT KVYEFNDSDQ DSAFNTIDKW LDSASAGRAN ISPEKIPWDA
IRSLLKQSIY GGRIDNEYDQ RLLDSFVNTL FTPECYDIDF QVVKGNGENE QSLAVPDGTK
IEHFLEWVNK LPDREPPTWL GLPSNAERVL LTLKGNQMLN KVRKMKSLSD DDEAAFSQDG
ASGQKTASAG AAAAASNSNQ PAWMRALSAS ITNWLSLLPS NIKTMQRDSH GIMDPLFRFF
ERENQIARNL LRVIREDLIS LQKVCAGELK QTNHLRQLMS WLNKGLIPDH WKRYKVPKSI
SLNAWLADLK TRLEQVELIA QEQTFENVDI AIGNLFTPEA YITATRQATA QRYKWSLEEL
ILDVDIGECK QMDSLGYRIH GMKIEGGKWN ENEICLTSEP SNKLPKTTIR WIRKDQKEEN
ENIVELPVYL NSDRSDLLFT IRTCANKEEK DRIPQRAVAV VISF
//
