ID   I1C3J3_RHIO9            Unreviewed;      1068 AA.
AC   I1C3J3;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RO3G_07728 {ECO:0000313|EMBL:EIE83023.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE83023.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE83023.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476736; EIE83023.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1C3J3; -.
DR   STRING; 246409.I1C3J3; -.
DR   VEuPathDB; FungiDB:RO3G_07728; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   InParanoid; I1C3J3; -.
DR   OMA; WPTELEA; -.
DR   OrthoDB; 1368576at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd00024; CD_CSD; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT   DOMAIN          664..822
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          957..1015
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   REGION          530..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1024..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1060
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1068 AA;  123219 MW;  B7FBF41341BD4522 CRC64;
     MNIGLTGVAY KYPGNEDDYS NRLKEDAQFL NMNFDANNEI EPNNSPYGTE DQQKQFMAYI
     QNAIDDNQNI PAGSFCTVPE SVVELPMEKG AKSFKRQYPI AHRQMPELEE QINEWLKAGI
     IKENRANTSF NSPLLMVPKK DENNEITSHR VCLDVRGINK PIPDVVYPVP KIRSIFDNLA
     GGEVFTKIDL KNAYNSFLVA PKDQHKLSFQ FKNRTYTFQG CCFGLKTVTA IFCKVMKILF
     ADMDFIETYV DDCVIKGTAD NHASNVKKVI ERLTSVNLKI NVKKCSWYQR SIYLLGFVVE
     SGGIIKVDPR RLTNIDSWPI PRNKKEVMRL MGIVSYMRDF IPLISRVAAP IDRLRNDLDV
     QNNWTQEHTD AFIALKEILK SKTLLHTPDL SKKFYVATDA SQYGVGAVLT QRDELNRTLH
     IAFASKSLSP SQRKWNTTKR ELYAVVFALE KYREFLWGNK FELRTDHKAL MYLHTQEQAN
     PMMIGWLETL LDFNFDVIHI QGILNQLPDL LSRLYEPCLN NEFMLGGGDA AQKENKKEKK
     ETKKKNKNKI KVKRQTNSTA KRHNLIYSQD KKLNVLAVKI KNKKFANNPT TDYMTPPPEK
     RARLLEDAHT FGHFGSTSIV EQLHSQGLHW NNIYKDATET IKSCIECQRH NISKKGYHPL
     KNILAYLPFD HIGIDLLGPL PVTANENVYV LVMIDVCTRY IILRPLKNKQ SDTVAKELIK
     IFGDYGIPKI IQSDNGREFK NSLMHSLSKH LGIDRRYSTA FHSRGNGVSE SAVKTTLNTI
     RKMVNSNSND WDDVLPIVQL ASNYKIRHRS KSAPFSLMFA RRLNSFEDYG DQSIADKIPN
     RPVTEQELIE RTDRMYQIVF PAIRERTQKI IEEASKRFND KNMIIDLPKD TAVMVRLPGR
     TSKLSPLYEG PYIVVRKTQG GSYVLKDEQN ELLHREYVPS ELKVVSIDET AIEDTYYEVE
     DIRDHRGGPG QREYLVKWAG YGERENTWEK ASSFSSTVPI DKYWLKRKEL KELEQARKQK
     MIANEKDYTK KTSARPNVTE ENKNHKRKDM VQDSTVLRKS KRIRNNRN
//