ID I1CFW3_RHIO9 Unreviewed; 826 AA.
AC I1CFW3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_12054 {ECO:0000313|EMBL:EIE87343.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE87343.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE87343.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476741; EIE87343.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CFW3; -.
DR STRING; 246409.I1CFW3; -.
DR VEuPathDB; FungiDB:RO3G_12054; -.
DR InParanoid; I1CFW3; -.
DR OrthoDB; 1365302at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 1..102
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 420..578
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 710..768
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 780..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 94862 MW; 81E679B70FE65ED1 CRC64;
MNEEHAHKLA FSWNSVQYIP VGTPFGLKHV SSVMQRTMSI ALENMSFAKC FVDDIVVAST
SIEEHKQHLK QVIDKLTKVN LKLNPDKCTF FQRKINLLGF RISPKGVSLD LRKVANVQEF
PVPKTGKDIM RYCGLINYFR PHIPKASALL APLDALRNEK SLIKLWNDKH QQCFDNLKKV
LLENVILSYP DMNQPFYVAT DASNVGIGVI LYQKINGKVH YISMIAKTLS KSERNYSATK
RELLAVVYAL KRFHKYLWGN KFTLYTDHKA LTYLHTQKIA NAMLINWFDT LLQYDFKVVH
LPGVDNILPD TLSRLYEIED PVNELGGDKP HLLNRAAVKL PSEDKGEYMT PPDPEERKLL
LLREHIKGHF GSDAIYHALK RKGIYWSNLK NEAVELVKSC IPCQQFNIIK KGYNPLRPIT
ATLPGDSWGI DLAGPMKTSL NGNNYLLIMV DIATRYCVLK PLPDKQSMTI VKALIDVFSH
YGFPRVIQSD NGGEFVNELM QLLAENAGYD HRLISSYHPR ANGVSERWVQ TAVNAIKKQI
EGAKADWDLY VPSTQLYLNG KHNERTKTPP FTLMYARNMN DFEDFSKEKN KATKEEINKQ
LLLNIKRMTE IVFPAIYERT KIITNNQKEK FDASHKLITI PENSYVMVKV NIKTNKLDPN
YEGPYKVKRI TQGGSYVLED EMGELLSKNY PPSALKLISQ DEVISTDKFY QVEAILAHKK
LKGKYLYKCR WKGYDKSDDT WEPASNFTDP KFITEYWQRV GIVPEDIKYR YDLQNNKGKS
NNVKLINTSH TGKRKTRTDL NENSHSSTTS SNKVNGNINS KRSRRY
//
