ID I1CRH6_RHIO9 Unreviewed; 373 AA.
AC I1CRH6;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Sterol 24-C-methyltransferase {ECO:0000256|RuleBase:RU362025};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
DE AltName: Full=Delta(24)-sterol C-methyltransferase {ECO:0000256|RuleBase:RU362025};
GN ORFNames=RO3G_15767 {ECO:0000313|EMBL:EIE91056.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE91056.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE91056.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- FUNCTION: Catalyzes the transfer of methyl groups from S-adenosyl-
CC methionine to the C-24 of sterols. {ECO:0000256|RuleBase:RU362025}.
CC -!- PATHWAY: Steroid metabolism. {ECO:0000256|RuleBase:RU362025}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
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DR EMBL; CH476748; EIE91056.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CRH6; -.
DR STRING; 246409.I1CRH6; -.
DR VEuPathDB; FungiDB:RO3G_15767; -.
DR eggNOG; KOG1269; Eukaryota.
DR InParanoid; I1CRH6; -.
DR OMA; NGIATMM; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362025};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Steroid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Steroid metabolism {ECO:0000256|RuleBase:RU362025};
KW Sterol biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Sterol metabolism {ECO:0000256|RuleBase:RU362025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 78..373
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 373 AA; 42040 MW; 7FF271D3DE98A193 CRC64;
MTVSTVSTNH AEDYAYARAL HGDKIKSGLI SNLRSKNAEV HHATTDAYLN LWKEKVANET
KEDEETRKGD YTTLVNSYYN LATDFYEYGW GSSFHFCRFY VGEEFGRAIA RHEHYLAAHL
GIKKDMRVLD VGCGVGGPAR EIAHFTGAHV TGLNNNAYQV ERAKHYAAKE LLQDQTEFIK
GNFMEMPFED NTFDAVYAIE ATCHAPTFEG IYGEIFRVLK PGGSFGCYEW VMTDNFDENN
PEHRQIAHEI EIGNGIPKMR TAQECIAALE HVGFNVEMNH DLANMGDAIH WYYPLEGDIR
KCQTLKDVIT TFAMTKAGRF TTTNLVRLLE KVGLAPKGTV ETQRVLETAA DALVTGARDN
LFTPMYFFVA KKP
//