ID I1CVY5_RHIO9 Unreviewed; 1609 AA.
AC I1CVY5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=RO3G_17326 {ECO:0000313|EMBL:EIE92615.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE92615.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE92615.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; GG669520; EIE92615.1; -; Genomic_DNA.
DR STRING; 246409.I1CVY5; -.
DR VEuPathDB; FungiDB:RO3G_17326; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1CVY5; -.
DR OrthoDB; 5303668at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 564..580
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 752..936
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1287..1446
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..95
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1609 AA; 184905 MW; 163110281E4EA15F CRC64;
MEDAPLNNAR CAISGEKKNA SRSSKSVSKS KSSIPEKLKR FNRKYDETAD LLDKLVEKRD
LEEDESKRKA LKIQIREYRE DLDYYEERIT KLEVSANGIS QKINEVGNNA NNTRESEPTV
PIKVIPPFRL LVSAAYNPKY YSSSKVSPDD VKNDNAFKTV KDFIRKFEAI VKHYGVNIDK
NWLGYLQLSI ENGQDDRSIN WLQHKLTVAD FKNSNWEGAK TALIGKFEAI VKHYGVNIDK
NWLGYLQLSI ENGQDDRSIN WLQHKLTVAD FKNSNWEGAK TALIGKFEAI VKHYGVNIDK
NWLGYLQLSI ENGQDDRSIN WLQHKLTVAD FKNSNWEGAK TALIGKFGES FTYLQYRQKL
MRIKQPNGEY LNIKQQDAFH RRMQEDLPWF EKSGTISVQA CRQEGTKANR NEKKVSWRRA
EVLPENKNRE RNFHKRPAHS APKCRYCGEK YTPGHLDKCR EIEKRRDHYL NKDTGFRARK
DAPKNYTGNF SQRRRSFEEK IHNANDSRIT VHNIEKVEKQ TTTEPEIMQT HPADEVMNDL
LNDDEIISPF QKALKQIREK KKHKQALVDT GADVSFISKN AVNKLKLRII PVHGSLLLAD
KEKTVKRLGV TDKLNVGYKG QTVAHEFEVL NMHDKVDAIF GRDILPRLGI HLVGVATNWD
DNKVKFDDSI EDSEYIPNVS NAGTPEEHEA LLQALQSHID KNQQIDVHSL CNLPEAVVKL
DTPHGKHAHV RQYPIANKMM PIFDEAVKTW LENGVIVRAP PSPWNSPITF APKKDANGNP
TDYRPCIDPR KINALLESDN YPLPLIDDIF HDLAGSTIFT SLDLKSAFHR LPIRKSDQVK
TTFTHRNKQY MFRSAPFGLK HVSSHFMRIM NLILSDLSNV HVYVDDIVIG TTGDSMEKHY
QAVSAVIDRL TQHNMILNPQ KCHFGKRSVH LLGFCISEKG KSLDPRKLTN IADWPRPKTG
REMMQWLGTV NYFRAHIPCA ATLTAPLDAL RNVAFIDDID WTPELQVHFQ SIKDILCSNV
VLSPYDPTKS LYVATDASNT GVGAVLFQKF DEKQSDGLTV TTIKYLGFMA RSLSQSERNY
SVTRRELLAI VFALKKFHKF LYGHHFTLYS DHRALTYLFT SDELNPMMVG WMDTLLSYDF
DIVHIPGVQN VLPDALSRLF PPEKELAGSD SNNSTVKHQN LAYKPNLKKE HELKMKKENR
KVFYVQSPTK FSDKDYITPP YEDRQEILDG VHKFGHFGAD HIVKSIHNQN LHWPNLLADA
VNYVSKCNTC QKYNIAKKGY NPHRPVYAYV PGDAYAFDLI GPFQSSSNMY TYVLILVDIC
TRFCVLKPLV HKKAKTVAGA IVDTFSLLGY PRHFVCSDNG SEFKNEILEN LFNAMGIDKR
YTTPYHPSAN EAAERYVQSA KKILAKFLEG ATEDWHHYIP SVQLMINNKI STRLQTTPFS
LMFARNINDF IEYRDDAGEL KKKEYMPHDE LLKRIDYMSQ VVFPAIQDRT DLYTKRQKEK
ADSKNRQSTF PEGSYVMVRD REQYNSLSPV YKGPYRVVRQ VQGGAYILRD VDETLMSRNY
SPEELKLISQ DEIIPKDELY EIEAIINHRG EPGNREYSGS KYLTNLSTF
//
