ID I1CYC6_9PSEU Unreviewed; 1057 AA.
AC I1CYC6;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SacglDRAFT_00754 {ECO:0000313|EMBL:EIE97700.1};
OS Saccharomonospora glauca K62.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=928724 {ECO:0000313|EMBL:EIE97700.1, ECO:0000313|Proteomes:UP000005087};
RN [1] {ECO:0000313|EMBL:EIE97700.1, ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|EMBL:EIE97700.1,
RC ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Land M.L., Hauser L., Brambilla E., Klenk H.-P., Woyke T.J.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Held B., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Brambilla E.-M.,
RA Klenk H.-P., Woyke T.;
RT "Noncontiguous Finished sequence of chromosome of Saccharomonospora glauca
RT K62.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CM001484; EIE97700.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CYC6; -.
DR STRING; 928724.SacglDRAFT_00754; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR HOGENOM; CLU_004900_0_0_11; -.
DR Proteomes; UP000005087; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005087}.
FT DOMAIN 7..319
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 324..622
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 705..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1057 AA; 113510 MW; 99F46BA98704BD43 CRC64;
MRPVPPQTWD EGARWLLAEP RGFVRVLGAP GTGKTTLLAT TAAARIAEGA DPESVLVLTA
SRKSADAVRS EITRRLTILD DTRAEIRTVR EPLVRTVHSY AFAVLRAQAA RDGVPAPRLL
SGPEQDVVVR ELLAGDLERG APDWPEPLRP ALAVPGFAEE LRDLLLRAAE RGLGPEDLVT
LGRRQGRPEW VAAGHFWSQY EQVTLLQGVG GHAVGEPGAP ALDAAELVSS ALVELEGDPG
LLAGERQRIR HLFVDDAQHL DPLQYRLVRL LAATASDAVL AGDPDQAVFS FRGADPRLLA
DADPDGTHTV VLERSHRLAP AVYETVARIA GTLPGTSAHR FVSPAPNATA GTVRVRLLPT
ATAEAAWVAD QLRRAHLLDG VPWSEMAVLM RSATQSLPLL QRALATAGVP VATVVEELPL
AQQPAVRPLL TVLKVAAEPW SLDAETAEML LSSPLGGADP LALRRLRRGL RRLESVAGGE
RSSDELLVEA LRDGDVLAGL ADAEALPVRR VGRLLTTASE AIREGVGVPE VLWRVWETSG
LQDRLVAQAG RGGVLGARAD RDLDAVVALF DAAARYVERL PKASVAGFAE YLSSQHIAGD
SLAPVAQKGT GVSLLTAHAA VGREWTVVAV TGLQEGTWPD LRLRGSLLGV ERLVDLLSGV
DDDAMSAVSA TAPILAEERR LFYVAASRAR RTLLVSAVQG EEEQPSRFLS ELTDSGEDVG
RGGPRTPVEE RERGLTLAEL VGELRAAVTD PDADLGRRRL AARQLARLAR AGVPGAHPSQ
WYGVSGPSTD RPLRGPDEII RVSPSVVDTL VKCPLRWLLE RHGGTDPAQL SAVTGTVVHA
LAQAAAEGAD ERTLWKELDA AWAKVDAGAP WFSRRERDRV EAMVRNFLAW FRRSRATLTQ
HAVEQDMRVE LPASEGEPRV ALTGRVDRLE LDEEGRPVVV DLKTAKEAVS ERAAAEHPQL
AVYQLATLLG AFSEHSGTTG GAKLLYVAKS NKKDGATVRE QPPLDEEAAR RWLADVRRAA
ADTAGPTYRV KENVDCSRCP SRSACPLRPE GRQVTGE
//
