ID I1E345_9GAMM Unreviewed; 254 AA.
AC I1E345;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=RNAN_3749 {ECO:0000313|EMBL:GAB60723.1};
OS Rheinheimera nanhaiensis E407-8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Rheinheimera.
OX NCBI_TaxID=562729 {ECO:0000313|EMBL:GAB60723.1, ECO:0000313|Proteomes:UP000004374};
RN [1] {ECO:0000313|EMBL:GAB60723.1, ECO:0000313|Proteomes:UP000004374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E407-8 {ECO:0000313|EMBL:GAB60723.1,
RC ECO:0000313|Proteomes:UP000004374};
RX PubMed=23209246; DOI=10.1128/JB.01922-12;
RA Zhang X.-Y., Zhang Y.-J., Qin Q.-L., Xie B.-B., Chen X.-L., Zhou B.-C.,
RA Zhang Y.-Z.;
RT "Genome Sequence of the Protease-Producing Bacterium Rheinheimera
RT nanhaiensis E407-8T, Isolated from Deep-Sea Sediment of the South China
RT Sea.";
RL J. Bacteriol. 194:7001-7002(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB60723.1}.
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DR EMBL; BAFK01000040; GAB60723.1; -; Genomic_DNA.
DR RefSeq; WP_008224541.1; NZ_BAFK01000040.1.
DR AlphaFoldDB; I1E345; -.
DR STRING; 562729.RNAN_3749; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000004374; Unassembled WGS sequence.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000004374};
KW Signal {ECO:0000256|SAM:SignalP};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..254
FT /note="D-lactate dehydratase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003638914"
SQ SEQUENCE 254 AA; 27614 MW; C059A96DA088DD05 CRC64;
MRLFTVLLCL FCIWFAVPAA AAQPVKKVLI VASNMVDMGD AEKHEARNDL FEFAPPYHVF
ISHGYDVDFV SPEGGAVPFM RDPLGIASYT IKYENFLDKA NNTLTPAQVK PEQYWAVFSG
GGYGVMFDVA QNVEIQAIIA KVYEAGGIVG VGGHGAASIA NVKLSGGDYL VKGKKVAGFP
NSTELEKTWA KHGTLLPFLI ESRLRDNGAL AQNKDTLADK HDVVIDQRIV STMFLPSAAL
VAKEMIILHQ QQGN
//
