ID I1H726_BRADI Unreviewed; 361 AA.
AC I1H726;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=100838729 {ECO:0000313|EnsemblPlants:KQK22389};
GN ORFNames=BRADI_1g66930v3 {ECO:0000313|EMBL:KQK22389.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EnsemblPlants:KQK22389};
RN [1] {ECO:0000313|EMBL:KQK22389.1, ECO:0000313|EnsemblPlants:KQK22389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK22389.1,
RC ECO:0000313|EnsemblPlants:KQK22389};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK22389.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK22389.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK22389}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK22389};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; CM000880; KQK22389.1; -; Genomic_DNA.
DR EMBL; CM000880; KQK22390.1; -; Genomic_DNA.
DR EMBL; CM000880; KQK22391.1; -; Genomic_DNA.
DR EMBL; CM000880; PNT77685.1; -; Genomic_DNA.
DR RefSeq; XP_003558261.1; XM_003558213.3.
DR RefSeq; XP_010228817.1; XM_010230515.2.
DR RefSeq; XP_010228819.1; XM_010230517.2.
DR AlphaFoldDB; I1H726; -.
DR STRING; 15368.I1H726; -.
DR EnsemblPlants; KQK22389; KQK22389; BRADI_1g66930v3.
DR EnsemblPlants; KQK22390; KQK22390; BRADI_1g66930v3.
DR EnsemblPlants; KQK22391; KQK22391; BRADI_1g66930v3.
DR EnsemblPlants; PNT77685; PNT77685; BRADI_1g66930v3.
DR GeneID; 100838729; -.
DR Gramene; KQK22389; KQK22389; BRADI_1g66930v3.
DR Gramene; KQK22390; KQK22390; BRADI_1g66930v3.
DR Gramene; KQK22391; KQK22391; BRADI_1g66930v3.
DR Gramene; PNT77685; PNT77685; BRADI_1g66930v3.
DR KEGG; bdi:100838729; -.
DR eggNOG; KOG1322; Eukaryota.
DR HOGENOM; CLU_029499_0_0_1; -.
DR InParanoid; I1H726; -.
DR OMA; EWMDCGN; -.
DR OrthoDB; 5486038at2759; -.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000008810; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IBA:GO_Central.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..233
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 361 AA; 39264 MW; AAA0CB1C2608FDDB CRC64;
MKALILVGGF GTRLRPLTLS VPKPLVDFAN KPMILHQIEA LKEVGVTEVV LAINYQPEVM
LNFLKDFESK LGITITCSQE TEPLGTAGPL ALARDKLADG SGEPFFVLNS DVISEYPFAE
LIQFHKSHGG EATIMVTKVD EPSKYGVVVT EKETGKVERF VEKPKVFVGN KINAGIYLLN
PSVLDRIELK PTSIEKEVFP RIAADNALFA MVLPGFWMDI GQPRDYITGL RLYLDSLRKK
APARLASGTH VLGNVLVHET ATIGEGCLIG PDVAVGPGCV VEAGVRLSRC TVMRGARVKK
HACISGSIVG WHSTVGKWAR VENMTILGED VHVCDEVYSN GGVVLPHKEI KSSILKPEIV
M
//
