ID I1IUP7_BRADI Unreviewed; 387 AA.
AC I1IUP7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=hydroxymethylglutaryl-CoA lyase {ECO:0000256|ARBA:ARBA00012910};
DE EC=4.1.3.4 {ECO:0000256|ARBA:ARBA00012910};
GN Name=100822477 {ECO:0000313|EnsemblPlants:KQJ92415};
GN ORFNames=BRADI_4g43510v3 {ECO:0000313|EMBL:KQJ92415.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQJ92415.1};
RN [1] {ECO:0000313|EMBL:KQJ92415.1, ECO:0000313|EnsemblPlants:KQJ92415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ92415.1,
RC ECO:0000313|EnsemblPlants:KQJ92415};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQJ92415.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ92415.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQJ92415}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQJ92415};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA;
CC Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57288; EC=4.1.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001651};
CC -!- PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-
CC methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-
CC methylglutaryl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00005143}.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; CM000883; KQJ92415.1; -; Genomic_DNA.
DR RefSeq; XP_010238769.1; XM_010240467.2.
DR AlphaFoldDB; I1IUP7; -.
DR STRING; 15368.I1IUP7; -.
DR EnsemblPlants; KQJ92415; KQJ92415; BRADI_4g43510v3.
DR GeneID; 100822477; -.
DR Gramene; KQJ92415; KQJ92415; BRADI_4g43510v3.
DR KEGG; bdi:100822477; -.
DR eggNOG; KOG2368; Eukaryota.
DR HOGENOM; CLU_022138_1_0_1; -.
DR InParanoid; I1IUP7; -.
DR OMA; GVANVWE; -.
DR OrthoDB; 1210873at2759; -.
DR UniPathway; UPA00896; UER00863.
DR Proteomes; UP000008810; Chromosome 4.
DR ExpressionAtlas; I1IUP7; baseline.
DR GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046951; P:ketone body biosynthetic process; IBA:GO_Central.
DR GO; GO:0006552; P:leucine catabolic process; IBA:GO_Central.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 93..360
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 387 AA; 41292 MW; A5A2006ECFBD7098 CRC64;
MSSLEEPLGL GDLPKLSINR LGRFCQSGCR ARADDRSNGN YTHSNGNDNQ TLFHSSSHSW
HLQGNYTDSS CNGIDMEFRA LPRKVSWDLP RFVKVVEVGP RDGLQNEKNI VPTSVKIELI
HKLVASGLSV VEATSFVSPK WVPQLADAKD VLEGVQYAPD VRLPVLTPNL RGFEAAVAAG
AKEVAVFASA SESFSKSNIN CTIEESLVRY RDVTSAAKKH GVRVRGYVSC VVGCPVEGAV
HPSKVAYVAK ELYDMGCAEI SLGDTIGVGT PGRVVPMLEA VMSVVPVDKL AVHFHDTYGQ
ALANILVSLQ MGVSIVDSSV SGLGGCPYAK GATGNVATED VVYMLHGLGI ETNINLGKLM
DAGDYICKHL NRTSGSKTAT ALCKLTA
//
