ID I1S2B7_GIBZE Unreviewed; 1822 AA.
AC I1S2B7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Chromosome 3, complete genome {ECO:0000313|EMBL:CEF87203.1};
GN Name=FG10904.1 {ECO:0000313|EnsemblFungi:CEF87203};
GN ORFNames=FGRAMPH1_01T20765 {ECO:0000313|EMBL:CEF87203.1};
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533 {ECO:0000313|EMBL:CEF87203.1, ECO:0000313|Proteomes:UP000070720};
RN [1] {ECO:0000313|EnsemblFungi:CEF87203, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF87203};
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2] {ECO:0000313|EnsemblFungi:CEF87203, ECO:0000313|Proteomes:UP000070720}
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF87203};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PH-1;
RA King R., Urban M., Hassani-Pak K., Hammond-Kosack K.;
RT "A revised Fusarium graminearum genomic reference sequence using whole
RT shotgun re-sequencing.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEF87203.1, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1
RC {ECO:0000313|EMBL:CEF87203.1};
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [5] {ECO:0000313|EnsemblFungi:CEF87203}
RP IDENTIFICATION.
RC STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084
RC {ECO:0000313|EnsemblFungi:CEF87203};
RG EnsemblFungi;
RL Submitted (JAN-2017) to UniProtKB.
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DR EMBL; HG970334; CEF87203.1; -; Genomic_DNA.
DR RefSeq; XP_011325476.1; XM_011327174.1.
DR STRING; 229533.I1S2B7; -.
DR EnsemblFungi; CEF87203; CEF87203; FGRRES_10904.
DR GeneID; 23557784; -.
DR KEGG; fgr:FGSG_10904; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G20765; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR InParanoid; I1S2B7; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000070720}.
FT DOMAIN 418..545
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1575..1819
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1494
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1822 AA; 201256 MW; 2C3CE4E4B635E117 CRC64;
MEMEVMEALE ASTADPLPPA SDLSTAPPAA TTVKDPTSTK TTHQPRSRSG SGLVAAPTAI
VTALRKRENT SPSFSTPTKW PSVRSTTTAA RMPASTTTAA KPLVPLSERR IHQTKHTPRS
LKDSDSSADN QGSLARWEIA PDGGSAGREG RQFTVANVGN NGRIYLRPTV RPAYQRCPQP
QFVFPITPPS TAGLDAIYQN KQVQDETSEL HVSQWTPTEP SPYDTNNRTY FEHDSYPLRP
VRHRRALSDS TVHEATVAKD SEPGAFKIVI SKPLEEYRPR TMEDLDSNDP LLDISIPSWR
IGVPRFTGRG TPMIRGSSYA PTEEFRSSSA SLLSRPQGVL NSSHPDIASP RRPNSMVVPM
LRLSRTMSAL TQTPSSAQFS KPVRPSWRSN SKVEPAMFDE LTFKPACDDR TLVKYSAATG
AVVAATPPRL VAEITSPSFL DYELISDFFL TFRAFLEPVD LCRMLIARLR WALARDDETG
MVVRVRTFVA LRHWILNYFM DDFVVDYNLR LVFCELLNDF VDELSQCNRG RKVQLKILGE
LKKCWRRVCA LYWDSPDFDD TLDSSVPVTP GGIAGHRDAS LDPSFWEQDG AETPRIESLL
PVRKSLAERT SFIADISRAG RVRDSVVVEP RPSTPDGQLT RDPMEGQQAS PVSMISMASM
DIVSCSFPTK IKPTAQPAAQ NHQTNPLAAH PVTATSNPHS GPVATTPRAL VGKRVRPQGA
HKRNNSLTDS LREHSTDKLS FKDQEFMMTA PYAGSLVRGN LLPPGQAYVD IDMQEFSNGL
LPMTSISQES QSLIKQRTPG SAMSGHGMKK LLGSVRRALS TRGQGTSSTQ GSFVSINNIG
PRGATTNRIP GTAVVPQNRQ RPSCPRPPVR IDLLGAEVVE DFKKAVRDEA AAEANRRGLP
PPMSPSTSLT PARDIQCSAA VYMDPNDFEQ LPHEYRHRPT SDMAITTGSK SIVIVDDTTP
FDPSLLHRIP TSNASVEAFA DAFKLTGADP TPPSTPPAGH STGTPRRSSY LLNQHLVRPS
LDEDPLPPFV PDFATLAPVT SAPISEDGNR VSYSHTARSS RNHPPVSLQN HRRLKSGKTH
RSLNSLLRRR SSATNALVRR SAVQSFDATT VSAPSVADPE PEEPMPKPLR ILRRRPGGDL
RAATNVGELD PVNTLRRSHS VGSLTTYSES IRSSFIQSPR MNSFGHGSFG RGSYTRGSYG
TGEVVSIDYT QHKSEAFSVG QLADKPRRDL SLFSTHSSKP AMRPSFEKEA QKLAQIPDDD
DDGGIESALA KLEGKFPERR AHKSAVGPPP LSRAVSDSVA THLLDVEHRK EHHEQQVVVR
ETFMFDAEDS EPEPMMESQD QHLTPQRPVT EAMSFLTGSS HNSYSSVPIL ERDSVKGRPW
TNISVLEGPD EETTPRAHKT LPYVGGEGDP QFASYDFVEK TKSIEGIKPG DTSPSVEEDQ
SFLEDDSDLS SEMSADAIEY EESDFGESVV PRVKLPAHPL GSPAPPPNRK PPSPPMTLVQ
ALEMSPTSCV HVPSLHEEQV WGQKPLPPTP ETTPTAPYVV VAERATIDGY RQAAKPESIE
SNKYSAHLPF ILAFDSEILA QQFTLIEKDA LNEIDWKELI DMNWKDAAHS DSRSWVDFLR
NSDAHGVEVV IARFNIMVKW AISEIVLTQG LEERVRCLTK FIHIATHCRR YRNFATLGQL
TIALSSNEVA RLTETWRHVP PQDLKTLQDL EQLVTPMRNF YNLRAEMETG SDQGCIPFVG
IYTHDLLYNA QRPSEMAGSP TTPPLINFER CRIAASVVKT LLRLLEASTR YKFHPIEGIT
ERCLWMSALS DEEIRRHSEM LE
//
