ID I1W6X7_ANGJA Unreviewed; 257 AA.
AC I1W6X7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR037109};
GN Name=HOXA9A {ECO:0000313|EMBL:AFI61959.1};
OS Anguilla japonica (Japanese eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7937 {ECO:0000313|EMBL:AFI61959.1};
RN [1] {ECO:0000313|EMBL:AFI61959.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23026207; DOI=10.1016/j.gene.2012.09.064;
RA Henkel C.V., Dirks R.P., de Wijze D.L., Minegishi Y., Aoyama J.,
RA Jansen H.J., Turner B., Knudsen B., Bundgaard M., Hvam K.L., Boetzer M.,
RA Pirovano W., Weltzien F.A., Dufour S., Tsukamoto K., Spaink H.P.,
RA van den Thillart G.E.;
RT "First draft genome sequence of the Japanese eel, Anguilla japonica.";
RL Gene 511:195-201(2012).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263, ECO:0000256|PIRNR:PIRNR037109}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037109, ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317, ECO:0000256|PIRNR:PIRNR037109}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ976895; AFI61959.1; -; Genomic_DNA.
DR AlphaFoldDB; I1W6X7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR PANTHER; PTHR45970; AGAP004664-PA; 1.
DR PANTHER; PTHR45970:SF3; HOMEOBOX PROTEIN HOX-A9; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037109};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037109};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037109};
KW Transcription {ECO:0000256|PIRNR:PIRNR037109};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037109}.
FT DOMAIN 189..249
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 191..250
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 150..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 27915 MW; 737A00BBED11B7AA CRC64;
MSAPGTLSSY YVDSLVLADA EYCSAPRYPA GAGLQSARPT ALPEHSEFGT CTFQTKPSAF
SASWGAVPTQ PPSGVSSVYH PYANPQATAG DSEGRYMQSW LLEPFAGSLP LTGIPSSQHC
AVKPEILAGG GAESTTLLLS DFASGSSPVD KSAVSSPSSL SQPAAESASV QEKAEADPNN
PVSNWLHASS TRKKRCPYSK HQILELEKEF LFNMYLTRDR RYEVARLLNL TERQVKIWFQ
NRRMKMKKTS KDGQKDD
//
