ID I1X9P2_9AQUI Unreviewed; 223 AA.
AC I1X9P2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Isoleucyl-tRNA synthetase {ECO:0000313|EMBL:AFI80338.1};
DE Flags: Fragment;
GN Name=ileS {ECO:0000313|EMBL:AFI80338.1};
OS Persephonella sp. ABE-1n.
OC Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC Persephonella.
OX NCBI_TaxID=1158323 {ECO:0000313|EMBL:AFI80338.1};
RN [1] {ECO:0000313|EMBL:AFI80338.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ABE-1n {ECO:0000313|EMBL:AFI80338.1};
RA Wagner I.D., Liu Y., Reysenbach A.-L.;
RT "Spatial Diversity Patterns of Aquificales from Deep-Sea Hydrothermal
RT Vents.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC IleS type 1 subfamily. {ECO:0000256|ARBA:ARBA00006887}.
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DR EMBL; JN856272; AFI80338.1; -; Genomic_DNA.
DR AlphaFoldDB; I1X9P2; -.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:AFI80338.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 55..223
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFI80338.1"
FT NON_TER 223
FT /evidence="ECO:0000313|EMBL:AFI80338.1"
SQ SEQUENCE 223 AA; 25635 MW; DBE7DE9BB0655914 CRC64;
LPANLGVMVN PEFDYVFLDN GKKVFIVAKE LLESFKEKTG IEGNVIKEVK GRELEFLEYK
HPFIDRVSKI YLSEFVELGT GTGLVHMAPG HGQEDYVIGQ RYGVEPFAPV DDEGRFTKEA
PEFIQGLRVF DANEPIIEKL KEVGALLHHE TIKHSYPHCW RCKNPVIFRA TPQWFIAMDA
VLENGNTLRG EAIKEIERVK WIPHWGENRI KSMVENRPDW CIS
//
