ID I2A664_BALAC Unreviewed; 257 AA.
AC I2A664;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=BMP4 {ECO:0000313|EMBL:AFJ32788.1};
DE Flags: Fragment;
OS Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9767 {ECO:0000313|EMBL:AFJ32788.1};
RN [1] {ECO:0000313|EMBL:AFJ32788.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21273216; DOI=10.1093/jhered/esq131;
RA Amaral A.R., Moller L.M., Beheregaray L.B., Coelho M.M.;
RT "Evolution of 2 reproductive proteins, ZP3 and PKDREJ, in cetaceans.";
RL J. Hered. 102:275-282(2011).
RN [2] {ECO:0000313|EMBL:AFJ32788.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaral A.R., Moller L.M., Beheregaray L.B., Coelho M.M.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ618290; AFJ32788.1; -; Genomic_DNA.
DR AlphaFoldDB; I2A664; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 156..257
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFJ32788.1"
FT NON_TER 257
FT /evidence="ECO:0000313|EMBL:AFJ32788.1"
SQ SEQUENCE 257 AA; 29493 MW; A2FC72ECA1BAD911 CRC64;
GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WEQGFHRINI YEVMKPPAEV
VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTRQGQ
HVRISRSLPQ GSGDWAQLRP LLVTFGHDGW GHALTRRRRA KRSPKHHPQR ARKKNKNCRR
HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL VNSVNSSIPK
ACCVPTELSA ISMLYLD
//
