ID   I2F2Q5_9BACT            Unreviewed;       435 AA.
AC   I2F2Q5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Uracil-xanthine permease {ECO:0000313|EMBL:AFK06208.1};
GN   ORFNames=Theba_0482 {ECO:0000313|EMBL:AFK06208.1};
OS   Mesotoga prima MesG1.Ag.4.2.
OC   Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX   NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK06208.1, ECO:0000313|Proteomes:UP000002881};
RN   [1] {ECO:0000313|EMBL:AFK06208.1, ECO:0000313|Proteomes:UP000002881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX   PubMed=22798451;
RA   Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA   Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA   Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT   "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT   MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL   Genome Biol. Evol. 4:700-708(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; CP003532; AFK06208.1; -; Genomic_DNA.
DR   RefSeq; WP_014730320.1; NC_017934.1.
DR   AlphaFoldDB; I2F2Q5; -.
DR   STRING; 660470.Theba_0482; -.
DR   KEGG; mpg:Theba_0482; -.
DR   eggNOG; COG2233; Bacteria.
DR   HOGENOM; CLU_017959_1_2_0; -.
DR   Proteomes; UP000002881; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   PANTHER; PTHR11119:SF3; LD30822P; 1.
DR   PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002881};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        50..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   435 AA;  45549 MW;  6FFB0E57D7F86358 CRC64;
     MSSENSAYQE VREQEDRSKN LGRGGLLVLG LQHAFTMFGA TVLVPYLTGV PVNVALFTAG
     IGTLLFHLLT KWKVPVFLGS SFAYIAPINA VILYHANAPE IYESVPEAIA AGFSITPDMI
     AYATGGILIA GLVQVAIAML IKRLGVSMFE KIFPPAVAGT IIAVIGLNLA PTAISMASSN
     WWIAIVSLGT AVLVRLYAKG FTRLIPVMCG IVVGYVVAAI TGNVTLDAVS QASWVGLPQF
     VLPKFSFYSL TVLVPVALAP TIEHFGDIFA VSAVVGKKYY EDPGIHRTLA GDGIATAVAG
     FFGGPANTTY SENTGVLAIT KVFNPIVMRI AAVFAIILSF VPKVGALIQS IPTAVMGGIE
     ILLFGMIAAI GMKTLIENRV KVDGKNLIIV SVMLVVGIGG AAIGIGPVRF EGIGLAALVG
     LLLNGIFVMT KAPEE
//