ID I2F8N1_9BACT Unreviewed; 417 AA.
AC I2F8N1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Isopropylmalate/homocitrate/citramalate synthase {ECO:0000313|EMBL:AFK08284.1};
GN ORFNames=Theba_2685 {ECO:0000313|EMBL:AFK08284.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK08284.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK08284.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
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DR EMBL; CP003532; AFK08284.1; -; Genomic_DNA.
DR RefSeq; WP_014731979.1; NC_017934.1.
DR AlphaFoldDB; I2F8N1; -.
DR STRING; 660470.Theba_2685; -.
DR KEGG; mpg:Theba_2685; -.
DR eggNOG; COG0119; Bacteria.
DR HOGENOM; CLU_022158_4_0_0; -.
DR Proteomes; UP000002881; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.260; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR PANTHER; PTHR42880:SF1; ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002881};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 41..294
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 417 AA; 46448 MW; 0FBDC37B16E38E68 CRC64;
MKPKDLEYMK LNGTPYFDDS RWVCPLNYEN KIRGKDAKDS IYIHDVTLRD GEQTCGLTWN
EDQRVRIGVA LNELGVKSIE VGMPIVSDEN KRAIRRLVDM KLDSEIVPFA RSLKKDIDES
LDCGATRVVI EHAVNPYDNE LVYGVSPEKL VDRVVSAILY AKEQGMKPTF MGWDATRSSF
DYVLKIFTEV AKQAKPESMV FVDSFGVASP FAIEFIFTEL RKAIPNIPFE FHVHNEFGLA
MGSVFAAVRA GVSGIHSSIN GLGERTGNVA TEEVAAGLKL LMGIDTGIDL SKIGYTSRLV
EDISKIQVAN NKPVVGKRLF WVESGIVVDA IDKLNKAGIN AAMTPYLPSL VGMGEIQVKL
GAFSGQASIK YWLKRLGIEA NEDQIEELTE IVRKEGRIRN TVLEIDEFKR IVGDFMK
//
