ID I2GX88_TETBL Unreviewed; 1032 AA.
AC I2GX88;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN Name=TBLA0A09560 {ECO:0000313|EMBL:CCH58740.1};
GN ORFNames=TBLA_0A09560 {ECO:0000313|EMBL:CCH58740.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH58740.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH58740.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR EMBL; HE806316; CCH58740.1; -; Genomic_DNA.
DR RefSeq; XP_004178259.1; XM_004178211.1.
DR AlphaFoldDB; I2GX88; -.
DR STRING; 1071380.I2GX88; -.
DR GeneID; 14493476; -.
DR KEGG; tbl:TBLA_0A09560; -.
DR eggNOG; KOG0207; Eukaryota.
DR HOGENOM; CLU_001771_0_1_1; -.
DR InParanoid; I2GX88; -.
DR OMA; GGKFMVC; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000002866; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 2.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 2.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 2.
DR PROSITE; PS50846; HMA_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 297..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 532..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 575..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 920..943
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 949..966
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 2..68
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 77..143
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1013..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..198
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1032 AA; 116165 MW; 3B8F33B543BE5657 CRC64;
MRELILNIGG LTCSSCIKTV TKALNKEPCV TSCNVSLTTC EAIIIYNENK GKINDIIESI
KKVGFEALKV TDTNLNRINK FSVEGMTCGG CTSKITTKLM SDDDIYRVDV SLITQECEVE
FNPQAMDSNK IQELIENCGF NCSIIASGDG EIESRLRGGD PMRRTALRIF NFDYYKDVDL
LKEQLEKLEQ DILIENVDDE RGVIAVQYDS SKIGIRSIFH KVEELGFQVI LDSPFDNSTQ
IKLLSKIKET KFWKMNCLIS GIFGIILLML YMWIPFLVSR FLIDETFPYN ESLIKGLFYR
DIFGFLIATY VQFYIGKYFY IKAFNSIKHC NGTMDTLVCI STSCAYIFSV YSIIKNIIIE
QEIEVVDRAE IVIRLPNVNF TTSIMLFAFI SFGKYLEQKA KSKTSTALKN LMSLTPSSCF
ILDEEDNMNL KEIPVDLLQD GDLINVSPGM KVPVDGIITY GESEVDESLM TGESVLVKKT
INDDVIAGSI NGPGTFIFRA THVGDETKLS FIIKTMKQAQ LIKAPIQRYA DYLASLFVPI
IILLAFLTFC FWFFVSQYYK GDDLPNIFQD EKYGNFYVCL RISISVIVVA CPCALGLATP
TAVMVGTGMA AENGVLIKGG DKLEIFNKIK TIIFDKTGTI TTGKMKVIEM RFKHSKVEND
YYGENEYKQN EEYLIKCLIL LTRSSEHPVS KAIYSYLCER YPVRKSGEIE MIESKYSIGN
GIKGKFEIKG VSEDLVEIGI GQKTLYNNEE EYDDDKENDY TRSYVFLQNK VVAIIELNDQ
IKRDSYETIE YLKNRNYNVF MISGDNRRAT MKVSEEIGIP IDHVFSEVLP IEKCNIIKDI
KKNWPGNEYV AFVGDGINDS PSLATSDLGI SISSGTDVAI DTADIVILSN EESNSNTTIK
EVCYALDISK ATFATIKRNL FWATIYNILM IPISMGALSH WGITLDPMLA GLAMAMSSVC
VVLSSLRLKR WKPPVIGEEN ALTSKDDLVV FGTWGNYLRH KLGTSWAHLR RAMGSSHQGR
PRDPEAQLEL IG
//
