ID   I2H0U1_TETBL            Unreviewed;       628 AA.
AC   I2H0U1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=Methyltransferase type 12 domain-containing protein {ECO:0000259|Pfam:PF08242};
GN   Name=TBLA0C01800 {ECO:0000313|EMBL:CCH59993.1};
GN   ORFNames=TBLA_0C01800 {ECO:0000313|EMBL:CCH59993.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS   10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH59993.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH59993.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000256|ARBA:ARBA00009725}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE806318; CCH59993.1; -; Genomic_DNA.
DR   RefSeq; XP_004179512.1; XM_004179464.1.
DR   AlphaFoldDB; I2H0U1; -.
DR   STRING; 1071380.I2H0U1; -.
DR   GeneID; 14494973; -.
DR   KEGG; tbl:TBLA_0C01800; -.
DR   eggNOG; KOG2361; Eukaryota.
DR   HOGENOM; CLU_029724_1_2_1; -.
DR   InParanoid; I2H0U1; -.
DR   OrthoDB; 5471626at2759; -.
DR   Proteomes; UP000002866; Chromosome 3.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR026113; METTL2/6/8-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809:SF11; METHYLTRANSFERASE-LIKE PROTEIN; 1.
DR   PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT   DOMAIN          466..570
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
FT   REGION          40..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..279
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  71277 MW;  35D9F0EF7F91EBE5 CRC64;
     MGVADLIKKF EKFAKVDDSD SKATAPAPIN AGATQVDKKT LNKSIEKDNT IEEKDDAIVM
     ETPAISEEPI SKEESSIEVP EVKKDKEVES TKESESIKEA EPAKAVEFVK EAEPSKEVVP
     VKEDVSAKIE EPVKEVEPVK KVEPVKKVEP VKKVEPVKEV ESVKEVEPVK EVEPVKEVEQ
     VKEKEPIKEE EPIKEEEPVK AEEPVKEADI PEVSIKENIE NPKPTEKFEI ETVASTEANP
     SSEAPSTSDP TESIITPASS TTSSKKSKKN KKKNKKKNKK NNSQPESPSN EPISTTISRD
     INNLEVVADS LGKTDSNESK FIALTQDVKE EITDSINHDI SYSKEELDNI NENTPEPSRI
     GRDNPFEFGK RNLTEETDVW AHNAWDNVEW GDEQINDAQE KIKLQQEAPV SDFDKKLYNG
     NPARYWDIFY KNNKENFFKD RKWLQIEFPS LYAATKKDAP PTTIFEIGCG AGNTFFPILT
     ENENEDLRII AADFAPKAVE LVKNSENFNS KYGHACVWDL ANDKGELPEG VEEESVDIAV
     MIFVFSALAP NQWDQAMDNL FKILKPGGTI LFRDYGRYDL AQVRFKKNRL MEDNFYIRGD
     GTRVYFFTEE ELRDIFTKKY FRVEKNWY
//