ID I2JPR9_9GAMM Unreviewed; 838 AA.
AC I2JPR9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=DOK_00974 {ECO:0000313|EMBL:EIF44971.1};
OS gamma proteobacterium BDW918.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Spongiibacteraceae.
OX NCBI_TaxID=1168065 {ECO:0000313|EMBL:EIF44971.1, ECO:0000313|Proteomes:UP000003473};
RN [1] {ECO:0000313|EMBL:EIF44971.1, ECO:0000313|Proteomes:UP000003473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BDW918 {ECO:0000313|EMBL:EIF44971.1,
RC ECO:0000313|Proteomes:UP000003473};
RX PubMed=22740675; DOI=10.1128/JB.00678-12;
RA Kim S.M., Cho S.J., Lee S.B.;
RT "Genome Sequence of the Unclassified Marine Gammaproteobacterium BDW918.";
RL J. Bacteriol. 194:3753-3754(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIF44971.1}.
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DR EMBL; AJMK01000003; EIF44971.1; -; Genomic_DNA.
DR AlphaFoldDB; I2JPR9; -.
DR PATRIC; fig|1168065.3.peg.204; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_6_2_6; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000003473; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000003473}.
FT DOMAIN 30..319
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 320..590
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 51..58
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 838 AA; 92464 MW; DCCF8CBDCE9A9178 CRC64;
MAWPLSIKMG SEAQCQACYP ARPFLCLAFS MLTEEQQCIT RHRGGHARVM AVAGAGKTST
MVAYVLARLR EGMDPRLIRV VMFNKAAQED FSHKLRIAAG ASAQLPPVRT FHAMGRNLAM
SLAKEGHLAA FDPTPLGDVQ AGLEMLKALQ AAAGTSALRA AIRDEQQQWL DTFAGFVDLA
KSTLAAPEVS FALGGYPEQY QLFIEAFARF EQWRKAAARV SFADFLYDPC RLIANDPALA
DFLANRVELF VVDEFQDIND IQFFMLKTLA GARAKLQVVG DADQCIYEFR GAKPEYMLSY
FGDTYPHQSY QLSRTFRYGH QLALAAAQLI SHNQRRDPLL CISADSAAPS HVELCLQNPD
GAVFAQACEA QRAEGRAYSE MAFLCRTWAQ AAPVELALLK RGIPNRVMGG SRVLERSEIK
VLMSLLGLMA GEFTSQDPAE QHQQLFDILK FCELKIRHEV LRGYAERIVL SDFSALHRSE
DSLSFYQEKR LQSLATVLEQ LGGEREAGRG LRRFVNDLDL LNLMRDNALN REDGENRAAT
VSAFIEFVAL QGDQAPSAIL AMLAELSDQS GSAVTTAGAV TITTMHRSKG LEWPVVLLPN
LSAHYMPYQA GNRRRQELDH LEAERRLMYV AMTRAIKALY LFAPGLDATN GWATDQRPEL
HQLPSPFLAE MDLDLAQRLS SQIETGARQF DLPPRGSPTA SVAQRYLDAV VPDWQANTAV
SSVGYPELGA YLQHKRYGLG RVSDVDAVGL VVSFASTKRF FPRLLVSRVL QPAPESAVNA
ALEGADASAK DFCVGDILAH DKFGRGAVLA IDKHTIAVNF SAGRKTFRLD LFQAKKIA
//
