ID I3C8G8_9FLAO Unreviewed; 1477 AA.
AC I3C8G8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Heavy metal efflux pump, cobalt-zinc-cadmium {ECO:0000313|EMBL:EIJ39911.1};
GN ORFNames=JoomaDRAFT_2953 {ECO:0000313|EMBL:EIJ39911.1};
OS Galbibacter orientalis DSM 19592.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Galbibacter.
OX NCBI_TaxID=926559 {ECO:0000313|EMBL:EIJ39911.1, ECO:0000313|Proteomes:UP000004690};
RN [1] {ECO:0000313|EMBL:EIJ39911.1, ECO:0000313|Proteomes:UP000004690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19592 {ECO:0000313|EMBL:EIJ39911.1,
RC ECO:0000313|Proteomes:UP000004690};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Peters L., Chertkov O., Ovchinnikova G., Kyrpides N., Mavromatis K.,
RA Detter J.C., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Tindall B., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Improved High-Quality Draft genome of Joostella marina DSM 19592.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; JH651379; EIJ39911.1; -; Genomic_DNA.
DR RefSeq; WP_008613766.1; NZ_JH651379.1.
DR STRING; 926559.JoomaDRAFT_2953; -.
DR eggNOG; COG1538; Bacteria.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_10; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000004690; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004690};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1477 AA; 165266 MW; E9F985F18CFAA576 CRC64;
MINKIIAFSI NNKFIIGLLT LALIGTGIWS MMTVNLGSVP DITNNQVQVI TQSPNLATED
IEQFVTYPVE LSMGNLPGVT EIRSVSRFGL SVVTIVFEDD MGIYKPRQLV QEKLNEVRDQ
IPEKFGSPAM GPITTGLGEI YQYTIKPQKE YDTVYSPTEL RTIQDWIVKR QMTLVEGVVE
VNSFGGSIKQ YEIAINPEKL NALNVSISQV FDALQKNNVN TGGAYIEKNN MANFIRGEGL
IRSLDDIKSI VIKNENGVPV TIGDAAEEVQ FGSQVRYGAF TQDGREAVGG MVLMLKGANP
NKVIANVQDR METVEQSLPE GLSIEPFLDR SVLIERTTST VTQNLLEGAL IVIFALVILL
GSLRGGLITA TTIPLSLLFA FILMKQFNVW ANLMSLGAID FGIIIDGAVI IIEGTVYEIQ
KRMRSGKIKF NKAKMDEVAY DAGSTMMGSA FFGQIIILIV FAPILFLTGV EGKMFRPMAF
TFGFAMIGAI FLCLTYVPMM SALFMKPIQN KKNWFGKFER WLEKVSDKII GGIQKGYMPL
LKGALRLKFI VLGSAVVSLI VAGFIFSRMG GEFVPQLDEG DIAMQALIRP GSGLSETIDV
STKIEDILLE NFPEVETAVA RIGVADIPTD PMPMDIADMF IVLEKDMDNW TSASSKEELI
EKIKEKLNEE LTGVNLVFSQ PVELRFNELL TGVREDVAVK LYGEDLDLLA EKADKMAEII
QTIPGVGDVN PERTSGLPQM TVRFNRKKIA QYGLDIEKIN DYISAAFAGG TAGVIFEGEK
RFDMVIRFDE AHRQSIDDLR TLYIDLPDGT QVPIKEVADI SYVPGPMQIS RDNTFRRTYV
GVNARGRDVE SVVNDIQQKL DEELDLPPGY YITYGGEFEN LQRAKGRLQI VVPIALFLIF
VLLYFALQSF SQSIMIYIAI PLAAIGGIFA LWLRDMPFSI SAGVGFIVLF GVAVLNGLVL
INRFNSLKEE GVTSIKDRIF TGTKERIRPI MLTATTDIFG FLPMAFSSSA GAEVQRPLAT
VVIGGMLTAT LLTLVVLPVL YTFVEKRREK KEQNKLGSSN SRSLATILII GLMLGGTFSV
NAQSDEMSSE NPIQDSLQTI SLEEAKEMAI QNFPQLKAAQ LEIESEEVLR KTAYDFGNTQ
IFTGKEEVGN GSDGIYTQIG VQQQGIDVFG IAPRLKLQKE RVALAENALE LNTLEVEREV
SRAWASVYTS KKRYRVYKKM DSIFEDIERA ARIRYETEAT SKLEYLATSN QGNEVKIQLE
QSYRDYLKSI QRLNLWFVSD TIYDVPDLPV ETLDEPLNFL VESLENHPLL QVSEQRIDVA
KAVTRERKSE FLPKFQGQYG RQEIAGQSGF FQYQIGIQIP LFFGPELGRT QEAQVNRQIA
EQNFYQDKIE LETAYKNMRE DYIKWRNSWN YYRDEALPLA KEQQGGSVLA FKEGAIDYVT
FLQNIRDAIR IEVNAWSAFN DYLDSRYQLE YYLKNSN
//
