ID   I3IWB5_ORENI            Unreviewed;       582 AA.
AC   I3IWB5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Rho GTPase activating protein 18 {ECO:0000313|Ensembl:ENSONIP00000000905.2};
GN   Name=ARHGAP18 {ECO:0000313|Ensembl:ENSONIP00000000905.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000905.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000000905.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3IWB5; -.
DR   Ensembl; ENSONIT00000000904.2; ENSONIP00000000905.2; ENSONIG00000000717.2.
DR   GeneTree; ENSGT00940000157142; -.
DR   Proteomes; UP000005207; Linkage group LG15.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR   PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          247..446
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          47..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  66436 MW;  BEF99C1DC92465E3 CRC64;
     RKTGQYTLQH KSETASLKPH FSARLLILKD SLDELQMDDY WKEVENISSS GSAGERGEGE
     VQEEEPQKIP EEGEQEEAWL AEAGLAQLVD HSITEEDSAV FLSTLTRTQA AAVERRVASV
     QQTLRRRNRQ QLPNVRDIFR PPDKVKTETE LNVEVAFSEQ ALSYRDNHQS FKVTPSPNSA
     DDKLPNFKLL RDKTGQTRIG DLSPLDMKKV HRLVLVEMTA LFDTSGIDLK PAKALKVKTK
     ESGLFGVPLT TLLDQDQRRF PGTKVPLILQ KIINHIEEEG LHTEGLLRIP GVATRVKLLC
     QDLESSFYDG TFSWQQLKQH DAASLLKLFI RELPHPLLTV EYLNAFIAVN NLPTKKQQLQ
     ALNLLILLLP EANRDTLKAL VEFFQRVIEN QAKNKMTLNN VSVVMAPNIF MFKGFRSKVT
     EQQEFSMATS TANIVRLLIR YQNLLWTIPK FIMNQVRHQN MESQRKQKER AVRKLLKKIA
     IERPSEKTIP EVRETSQGII RVHAPQFSKI SMAVQLTEDL QACDVLTRFL SQDSSLAVKK
     DDLCLYEIGG NIKERCLDGE TYMKDLYQVN PTAEWVIRAM QR
//