ID I3IWH6_ORENI Unreviewed; 463 AA.
AC I3IWH6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Noelin {ECO:0000313|Ensembl:ENSONIP00000000966.2};
GN Name=OLFM1 {ECO:0000313|Ensembl:ENSONIP00000000966.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000966.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000966.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_003455537.1; XM_003455489.3.
DR AlphaFoldDB; I3IWH6; -.
DR Ensembl; ENSONIT00000000965.2; ENSONIP00000000966.2; ENSONIG00000000765.2.
DR GeneID; 100699959; -.
DR KEGG; onl:100699959; -.
DR eggNOG; KOG3545; Eukaryota.
DR GeneTree; ENSGT00940000156959; -.
DR HOGENOM; CLU_035236_0_0_1; -.
DR InParanoid; I3IWH6; -.
DR OMA; FVREYES; -.
DR OrthoDB; 2876896at2759; -.
DR TreeFam; TF315964; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR InterPro; IPR022082; Noelin_dom.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR PANTHER; PTHR23192:SF34; NOELIN; 1.
DR PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR Pfam; PF12308; Noelin-1; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00446}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 208..460
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT COILED 76..124
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 209..391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 463 AA; 52850 MW; 6BD3E4009C1823AB CRC64;
MCLSFEEKEM ESEENLLSAY LLLLLLGSHF TLVGPSTPEE GWQVYSSAQD SEGRCVCTVV
APQQTICSRD ARTKQLRQLL EKVQNMSQSI EALDQRSQRD LQFVEKMEVQ LKGLENKFKQ
VEDGHESNIA RQYKSIKAKM EELRPLIPVL ESYKADALLV RQFKEEAANV TKLLGSLQEQ
LGGLDYQELH SRVISLEDRL KACMQRLACG KLTGISEPIT IKTSGSRFGS WMTDPLAPAG
DNRVWYMDGY HNNRFVREYL SMSDFMMTDN FTSHRLPHPW SGTGQVVYNG SLYFNKFQSH
TIIKFDFSTS LISRSRQLDF AGYNNMYHYS WGGHSDIDLM VDEGGLWAVY ATNQNAGNIV
LSQLNPNTLQ IIRSWTTNHP KRSAGEAFMI CGTLYVTNGY SGGTKVYYAF STNSSTYEYI
DIPLTNKYSH LSMLDYNPRD RALYAWNNGH QVLYNVTLYH IIQ
//
