ID I3IWV3_ORENI Unreviewed; 1800 AA.
AC I3IWV3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001093.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001093.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 8128.ENSONIP00000038430; -.
DR Ensembl; ENSONIT00000001092.2; ENSONIP00000001093.2; ENSONIG00000000861.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000159855; -.
DR HOGENOM; CLU_000540_0_2_1; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 2.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 948..969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1094..1115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1296..1320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1455..1489
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1574..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 302
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 647
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 962
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1800 AA; 204457 MW; 23C0FA40162BEE57 CRC64;
MTRTDTLHST TSSTGTQRKR GQHAKKQGTN QVQRAPRALY CLKLNNPIRR AALHIVEWKP
FDIFILLAIF ANCVALGVSK PFPEDDSNST NHDLEQVEYV FLIIFTVETF LKILAYGLVM
HPSSYIRNGW NLLDFVIVIV GLFSVVLETM THKSSGEQAT THHMPGKPGG LDVKALRAFR
VLRPLRLVSG VPSLQIVLNS IMKAMVPLLH IALLVLFVII IYAIIGLELF IGRMHRTCYY
IGTGTIEHTD DPVPCAFAGH GRQCIINGSE CRGRWDGPNG GITNFDNFFF AMLTVFQCIT
MEGWTDVLYW MNDAIGFELP WVYFVSLVIF GSFFVLNLVL GVLSGSFSKE REKAKARGDF
QKLREKQQME EDLCGYMDWI TQAEDMDELD EDGNPRPSLG DLADKKRGKF GWFSHSNETH
GETHMQARLC LHHIREFLEP EVTFRTLRRW NRVCRRNCRT AVKSVTFYWL VLLLVFLNTS
LSASEHYNQP DWLTQVQDIA NKVLLSLFTV EMLLKMYSLG LAHYFVAFFN RFDCFVVCGG
IVETILVELE IMPPLGISVL RCVRLLRIFK VTRHWTALSN LVASLLNSMK SIASLLLLLF
LFLIIFALLG MQLFGGKFNF DETQTKRSTF DAFPQALLTC FQILTGEDWN MVMYDGIMAY
GGPVFPGMIV CIYFVILFIC GNSKTITLRS FTFLSPSRFS DGGVQLKMAD LAPPKEKVLP
IPEGSAFFCL SKTNPIRVAC HTLIHHHIFT NLILVFIILS SCSLAAEDPI RAHSFRNNIL
GYADYAFTSI FTVEILLKMT VHGAFLHQGS FCRNWFNLLD LLVVIFVSCM VCCISSAISV
VKILRVLRVL RPLRAINRAK GLKHVVQCVF VAIRTIGNIM IVTTLLQFMF ACIGVQLFKG
KFYRCTDEAK HTPEQCKGTF VVYKDGDVSH PMVRERIWMN SDFNFDNVLM GMMALFTVST
FEGWPALLYK AIDANGENSG PIYNYRVEIS IFFIVYIIII AFFMMNIFVG FVIITFREQG
EQEYKNCELD KNQRQCVEYA LKAQPLKLYI PKNPVQYKFW SIINSTGFEY VMFVLILLNT
VTLAIQHYEQ SKTFSYIMDI LNMVFTGLFT LEMLLKLAAL RIRVRKPNHY FVDAWNSFDA
LIVVGSVVDI VVTEFSVSTC DSGEDSSRVS ITFFRLFRVM RLVKLLSKGE GIRTLLWTFI
KSLQALPYVA LLIAMIFFIY AVIGMQTFGK IAMQDYTQIN RNNNFQTFPQ AVLLLFRCAT
GEAWQEIMLA SLPGKRCDPE SDYEPGEEFS CGSNFAIVYF ISFFMLCAFL IINLFVAVIM
DNFDYLTRDW SILGPHHLDE FKRIWSEYDP EAKGRIKHLD VVALLRRIQP PLGFGKLCPH
RVACKRLVAM NMPLNADGMV TFNATLFALV RTALKIKTEG NPEQENEELR VIIKKIWKRM
KPKLLDEVIP PHEGTLEVTV GKFYATFLIQ DYFRKFRRRK EKGDLTGEND SPNPSAVQLC
KAGLKTLQDL GPEMRLALNE DLEEEEEAMM EDEEMEENAA YKWKTDSFPL CVCRHYPDEP
PLYRDHYDGH PSYTNSSYGN GYSEGRRTTR RRLLPATPTG RKPSFNIQCL RRQGSSDDLP
IPGTYHPTSP PRHTRTQVKH TASTHTHTNL SSSVKSNTLL SSANVQQLRV SSLLRSLHGA
PPPYRAYTTL RVPSHLGAPF TEKRGSADSL VEAVLISEGL GLYARDPKFV AFAKREIADA
CHMTVDEMES AASDLLGSGS HSFLSNAASD HAALYSDEEP IRTGHDEDEL ADEMTCVTSF
//
