GenomeNet

Database: UniProt
Entry: I3IWV3_ORENI
LinkDB: I3IWV3_ORENI
Original site: I3IWV3_ORENI 
ID   I3IWV3_ORENI            Unreviewed;      2029 AA.
AC   I3IWV3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001093, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000001093}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000001093}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000001093}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01046654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01046655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000001093; -.
DR   Ensembl; ENSONIT00000001092; ENSONIP00000001093; ENSONIG00000000861.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410YA8V; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3IWV3; -.
DR   OMA; LNQTECR; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     54     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     93    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    124    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    281    302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    602       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    868    888       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    900    926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    946    976       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1030   1051       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1071   1098       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1150   1170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1176   1197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1285   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1376   1400       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1534   1568       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED     1594   1618       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2029 AA;  229501 MW;  89CD7E29CAA2A1A1 CRC64;
     STTSSTGTQR KRGQHAKKQV QGTNQVQRAP RALYCLKLNN PIRRAALHIV EWKPFDIFIL
     LAIFANCVAL GVSKPFPEDD SNSTNHDLEQ VEYVFLIIFT VETFLKILAY GLVMHPSSYI
     RNGWNLLDFV IVIVGLFSVV LETMTHKSSG EQATTHHMPG KPGGLDVKAL RAFRVLRPLR
     LVSGVPSLQI VLNSIMKAMV PLLHIALLVL FVIIIYAIIG LELFIGRMHR TCYYIGTDNY
     VEDDPVPCAF AGHGRQCIIN GSECRGRWDG PNGGITNFDN FFFAMLTVFQ CITMEGWTDV
     LYWMNDAIGF ELPWVYFVSL VIFGSFFVLN LVLGVLSGEF SKEREKAKAR GDFQKLREKQ
     QMEEDLCGYM DWITQAEDMD ELDEDGNPQE QKPNEPEIDV SETASENTEN IDEEHTNCCQ
     ACCAQMMKIG CCRTLRRWNR VCRRNCRTAV KSVTFYWLVL LLVFLNTSLS ASEHYNQPDW
     LTQVQDIANK VLLSLFTVEM LLKMYSLGLA HYFVAFFNRF DCFVVCGGIV ETILVELEIM
     PPLGISVLRC VRLLRIFKVT RHWTALSNLV ASLLNSMKSI ASLLLLLFLF LIIFALLGMQ
     LFGGKFNFDE TQTKRSTFDA FPQALLTCFQ ILTGEDWNMV MYDGIMAYGG PVFPGMIVCI
     YFVILFICGN YILLNVFLAI AVDNLAGGDS DDKKKDKKQE GAEEEVTEGE VDVDEDTEYE
     EEEELPEGDE ALQSLQLSVN NKCNTIKRTN VREYVNNSNA GATMNQEAAI RDFKGDENPE
     APYGGVQLKM ADLAPPKEKV LPIPEGSAFF CLSKTNPIRV ACHTLIHHHI FTNLILVFII
     LSSCSLAAED PIRAHSFRNN ILGYADYAFT SIFTVEILLK MTVHGAFLHQ GSFCRNWFNL
     LDLLVVSVSL VSFFLHSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN
     IMIVTTLLQF MFACIGVQLF KGKFYRCTDE AKHTPEQCKG TFVVYKDGDV SHPMVRERIW
     MNSDFNFDNV LMGMMALFTV STFEGWPALL YKAIDANGEN SGPIYNYRVE ISIFFIVYII
     IIAFFMMNIF VGFVIITFRE QGEQEYKNCE LDKNQRQCVE YALKAQPLKL YIPKNPVQYK
     FWSIINSTGF EYVMFVLILL NTVTLAIQHY EQSKTFSYIM DILNMVFTGL FTLEMLLKLA
     ALRIRHYFVD AWNSFDALIV VGSVVDIVVT EFSPAACNPV KSGEDSSRVS ITFFRLFRVM
     RLVKLLSKGE GIRTLLWTFI KSLQALPYVA LLIAMIFFIY AVIGMQTFGK IAMQDYTQIN
     RNNNFQTFPQ AVLLLFRCAT GEAWQEIMLA SLPGKRCDPE SDYEPGEEFS CGSNFAIVYF
     ISFFMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWSEYDP EAKGRIKHLD
     VVALLRRIQP PLGFGKLCPH RVACKRLVAM NMPLNADGMV TFNATLFALV RTALKIKTEG
     NPEQENEELR VIIKKIWKRM KPKLLDEVIP PHEEEEVTVG KFYATFLIQD YFRKFRRRKE
     KGDLTGENDS PNPSAVQLCK AGLKTLQDLG PEMRLALNED LEEEEEAMME DEEMEENAAF
     SVSTSPPFAG QGGVVGDGGV SNGGLIHRVG SLTKMANGSD QDEHLRRGDS MRTACWTTAT
     KDRHTTKEGR RSHNGNYLHG IDMCDSQLQS PPPQPLSYAM VITSAPYRCN NSRRSREEDN
     DSITSRDRHY PDEPPLYRDH YDGHPSYTNS SYGNGYSEGR RTTRRRLLPA TPTAYLHHHT
     SCRKPSFNIQ CLRRQGSSDD LPIPGTYHPT SPPRHTRTQE IKHSPLLSKR STASSLVTPP
     VAPRRPPRHP GRTRALAAVA SSMLLFKPFS SIRCQRDRCG TQTSLVRRPC RDIRAYTTLR
     VPSHLGAPFT EKRGSADSLV EAVLISEGLG LYARDPKFVA FAKREIADAC HMTVDEMESA
     ASDLLGSGSH SFLSNAASDH AALYSDEEPI RTGHDEDELA DEMTCVTSF
//
DBGET integrated database retrieval system