ID I3IXY3_ORENI Unreviewed; 621 AA.
AC I3IXY3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=THUMP domain containing 2 {ECO:0000313|Ensembl:ENSONIP00000001473.2};
GN Name=thumpd2 {ECO:0000313|Ensembl:ENSONIP00000001473.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001473.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001473.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR RefSeq; XP_005473791.1; XM_005473734.3.
DR AlphaFoldDB; I3IXY3; -.
DR STRING; 8128.ENSONIP00000001473; -.
DR Ensembl; ENSONIT00000001472.2; ENSONIP00000001473.2; ENSONIG00000001165.2.
DR GeneID; 100707416; -.
DR KEGG; onl:100707416; -.
DR CTD; 80745; -.
DR eggNOG; ENOG502QSR4; Eukaryota.
DR GeneTree; ENSGT00530000063557; -.
DR HOGENOM; CLU_045692_1_0_1; -.
DR InParanoid; I3IXY3; -.
DR OMA; QWTSAVM; -.
DR OrthoDB; 5406466at2759; -.
DR TreeFam; TF313093; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 249..368
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 116..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 67911 MW; DED419161DAF07DE CRC64;
MDEPGSGGSV VRYYCTAGNG MEAFLINEVK TKLAAEDVCQ IPGKVLFSSS AKINRVSNLK
GAERLFLLLK QDSPVSLSAH TSTAKAASVL QSRLLGDKNQ WTSAVMTWRR LQGELTGRKN
TVKTSSPALG VTRKREDEMR GSDEQSREGE KSLVEFRTST GGERKEETDK QRSGGQNGVS
TMAQKRKRDD EEEKERKVAP WDTGIEKTVE KGKACEEERT REEEAEGMLV EFIDCTHGAD
VNGGGPVCDH TASRLEHRGA SSSKKMDDIA KDFTEESQEN VKTTGEKNKT LLTTCEDKPE
LLTCIPVSFR ISCKCSGSLS RCLGAQEVSR VIGAGLSRLL GWKADLKNPQ LEINVNLSDD
YCLLGIPLTR LPLANRSYIK ITGLRSTTAW AMASLAHIQP GFRVVDPMCG VGTILIEAAQ
EHKDACFLGV DIDEAQLQKA SENIAFAELE NRINLLKASS LVLPVPSATV DAVICDLPFG
RKFGSRIDMA ANLPLILTEM ERVLRPGGIL VLLLSPQLSC LLKKLLIQYD TGPKSNPETK
PQTGMQNCPS SSGSPSKKQT FQIHSGVKST PSQETKLQHS LPFTVSSLKH QATFRVSLGA
IDGLIHKYVK KDCCVFRDVM F
//
