ID I3IYE9_ORENI Unreviewed; 1967 AA.
AC I3IYE9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Myosin X, like 1 {ECO:0000313|Ensembl:ENSONIP00000001639.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001639.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001639.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8128.ENSONIP00000001639; -.
DR Ensembl; ENSONIT00000001638.2; ENSONIP00000001639.2; ENSONIG00000001298.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000164909; -.
DR HOGENOM; CLU_001626_1_0_1; -.
DR InParanoid; I3IYE9; -.
DR OMA; NMEFMLA; -.
DR TreeFam; TF316834; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd14873; MYSc_Myo10; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR036124; MYSc_Myo10.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF9; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 56..730
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1134..1232
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1314..1419
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1443..1602
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1607..1952
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1611..1721
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 609..631
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 784..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..800
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..990
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 150..157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1967 AA; 224885 MW; B4841FB38F32BB6C CRC64;
LRIYFILEKE QLLPATVNSC GDGTLVVTTD YGEVFYLQQA EVTRERVYAM HQSSIDGVED
MSALAELHEA AIMHNLYQRY QKDSIYTNIG SILAAVNPYK QIPGLYDLER VDLYSKHHLG
ELPPHIFAVA NECYRCIWKR HDSQCILISG ESGAGKTEST KLLLQFLSVM SQNSAGTPPS
EKSTRVEQAI VQSSPIMEAF GNAKTVYNNN SSRFGKFIQL HFSESGNIQG GCVIDCILNR
VVRQNPGERN YHIFYALLAG ASKEQKSLYF LEDPAESYHY LSQSGCLKDK SLNDKELFNS
VMEALKVLEF TEEEIRDMFK LLSGVLQLGN IEFMTAGGAQ ITTKQVVTNA SELLGLDAFQ
LSEVMTQRSI ILRGEEICSP LTIEQAIDSR DSVAMALYSQ CFSWIILKIN QKIKGKENFK
SIGILDIFGF ENFEVNRFEQ FNINYANEKL QEYFNKHIFS LEQLEYNREG VQWEAIDWMD
NAECLDLIEK KLGLLALVNE ESRFPKGTDF TLLEKLHSRH STNPYYVKPR LADHQFGIKH
YAGEVLYDVR GILEKNRDTF RDDILNMLKD SRLDFIYDLF EKVGSRNNEE KMGTARRKPT
VSSQFRDSLH ALMATLSVSN PFFIRCIKPN MEKTPNVFDP EVVLNQLRYS GMLETVKIRR
AGFPVRRTFK DFFSRYKIIL KEKVPTAGDD KKRTTDLLTK YDKTKKEWQL GKTKVFMKES
LEQRLEKDRD EVRRQAAMII RAHLLTFSYF KRARASVITL QKHLRRHIQC KRFVKQRKAA
VVLQKHRRGQ VARAHVRKLR GEKKKKEEEQ KTKEEEEKEK TLGEGETEEA KEEDEARQME
EILQLEREIE RLQKKREDEV SQLCESSKQE LQLRRDAELK RMKKEASRKA TELIDLLNFG
GVDPSLGAVG AKPAAEVKAS KGASTTRGAS KEEDVDEGFH AEEECIPLPD FPPPAETDAP
VDQDIFAQLP PPPPAFAEGT VPPAPPPPKV SMVESLVDGE EPIYSMPADT ESDYDQEEEE
GSVTAGDDSS VSGSNRGSAA VTDEEHPRKS TCTNASIESY RGSSDSYADS DDEHDGMMDT
DEEVTNGRVT LLNGNGPPYF HGYLYMKAGL MIPWRRRWCV LKDETFMWFR SKQESLKSGW
LYKKGGGLST LSRRNWKMRW FVLRDSKLMY YDNDSEEKLK GTIDIRAAKE IVDNHEKENA
LNIVTDERTY QVFAESPEDA SGWFNVLSKV RVCTPEQLLE MSHEQANPKN AVGTLDVGLI
DSVCASDNPD RPNSFVIITA NRVIHCNSDT PEEMHHWISL LQKPKGDARI DGQEFLVRGW
LQKEMKTNAK STSLKLKKRW FVLTHNSLDY YKSSEKNSSK MGTLVLNSLC SVIQPDERVH
RETGYWNIIV YGRKHSYRLY TKMLNEAMRW TAAIQGLIRD IKENSVNPEI VEQMYRRNPI
LRYTQHPLHA PLLPLPYGEV TSLQRQQGYA SLQDEAVRVF NSLQEMETLA DTVPIIQGIL
QTCQDLRPLR DEVYCQVIKQ TNHVPQPNSP ANRAHWHLLT CMSCTFLPSR AILRYLRFHL
KRIRERYPGA EIERYATFIG ESLKKTKSRE FVPSQEEIAA LLLRQEMSTT VYCHGGGSCK
ISINSHTTAG EVVEKLIRGL AMEESKNLFS LFEHNGFTDR ALESRVIVAD VLAKFERLAG
SEEEEEEGEW KLYFKLYCFL DVESMPKEGV EFAFMFEQAH ESLISGHFPA SEETLQHLAA
LRLQYLHGDG AGRAGWSLGS VYPIGRLRNR ILHSTKPGGV GTGVEKRKTP SFLDGTLRRS
FKTGSLKKQK MEDEQMLEMW VKEETSATRT SVLEKWTRLQ GMPQHQAMLK YMSIIKEWPG
YGSTLFDVEC KEGGFPHDLW LGVSADNMSV YKRGEPKPLE TFQYEHITFF GASQPCTYKI
IVDEREMYFE TPLVGEITKI MRAYINMVVK KRCSIMSVSS VASAWGR
//
