ID I3IZY4_ORENI Unreviewed; 1908 AA.
AC I3IZY4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Myosin heavy chain, fast skeletal muscle {ECO:0000313|Ensembl:ENSONIP00000002174.2};
GN Name=LOC100712344 {ECO:0000313|Ensembl:ENSONIP00000002174.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002174.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002174.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8128.ENSONIP00000038228; -.
DR Ensembl; ENSONIT00000002174.2; ENSONIP00000002174.2; ENSONIG00000030466.1.
DR GeneTree; ENSGT00940000162888; -.
DR HOGENOM; CLU_000192_13_0_1; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 6.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..739
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 616..638
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 803..1617
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1646..1884
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 145..152
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1908 AA; 218475 MW; 81F927121CD836AC CRC64;
MSTDAEMEQY GAAAIYLRKP ERERIEAQTA PFDAKTAFFV VVPEEMYVKG KLVKKEGVDA
DLDFLFRRSL QLCFFTFLCL LCTYSGLFCV VVNPYKWLPV YDATCVAAYR GKKRIEAPPH
IFSISDNAYQ FMLTDRENQS VLITGESGAG KTVNTKRVIQ YFATIAALGG KKAEPTPGKM
QGSLEDQIVA ANPLLEAYGN AKTVRNDNSS RFGKFIRIHF GTTGKLSSAD IETYLLEKSR
VTFQLSAERS YHIFYQLMTG HKPELLEALL ITTNPYDYPM ISQGEITVKS INDVEEFIAT
DTAIDILGFT AEEKLSIYKL TGAVMHHGNM KFKQKQREEQ AEPDGTEVAD KIAYLLGLNS
ADMLKALCYP RVKVGNEMVT KGQTVPQVNN AVSALCKSVY EKMFLWMVIR INEMLDTKQP
RQFFIGVLDI AGFEIFDFNS LEQLCINFTN EKLQQFFNHH MFVLEQEEYK KEGIQWEFID
FGMDLAACIE LIEKPMGIFS ILEEECMFPK ASDTTFKNKL HDQHLGKTKC FEKPKPAKGK
AEAHFSLVHY AGTVDYNISG WLDKNKDPLN DSVVQLYQKS SNKLMCLLYA AGGGKKGGKK
KGGSFQTVSA LFRENLAKLM TNLRSTHPHF VRCLIPNETK TPGLMENFLV IHQLRCNGVL
EGIRICRKGF PSRILYGDFK QRYKVLNASV IPEGQFIDNK KASEKLLGSI DVDHTQYMFG
HTKVFFKAGL LGTLEEMRDE KLAELVTMTQ ALCRGYVMRK EFVKMMERRE SIFSIQYNIR
SFMNVKNWPW LKLYFKIKPL LKSAETEKEL QNMKENYEKM QTDLATALAK KKELEEKMVG
LLQEKNDLQL QVAAEVDNLS DAEERCEGLI KSKIQLEAKL KETSERLEDE EEINAELTAK
KRKLEDECSE LKKDIDDLEL TLAKVEKEKH ATENKVKNLT EEMASQDESI AKLTKEKKAL
QEAHQQTLDD LQAEEDKVNT LTKSKTKLEQ QVDDLEGSLE QEKKLRMDLE RAKRKLEGDL
KLAQESIMDL ENDKQQSDEK IKKKDFEISQ LLSKIEDEQS LGAQLQKKIK ELQARIEELE
EEIEAERAAR AKVEKQRADL SRELEEISER LEEAGGATAA QIEMNKKREA EFQKLRRDLE
ESTLQHEATA AALRKKQADT VAELGEQIDN LQRVKQKLEK EKSEYKMEID DLSSNMEAVA
KAKGNLEKMC RTLEDQLSEL KAKNDENVRQ LNDINAQKAR LQTENGEFGR QLEEKEALVS
QLTRGKQAFT QQIEELKRHV EEELKAKNAL AHAVQSARHD CDLLREQFEE EQEAKAELQR
GMSKANSEVA QWRSKYETDA IQRTEELEEA KKKLAQRLQD AEESIEAVNS KCASLEKTKQ
RLQGEVEDLM IDVERANSLA ANLDKKQRNF DKVLAEWKQK YEESQAELEG AQKEARSLST
ELFKMKNSYE EALDHLETMK RENKNLQQEI SDLTEQIGET GKSIHELEKA KKTVETEKSE
IQTALEEAEG TLEHEEAKIL RIQLELNQVK GEIDRKLAEK DEEMEQIKRN SQRVIDSMQS
TLDAEVRSRN DALRVKKKME GDLNEMEIQL SHANRQAAEA QKQLRNVQGQ LKDAQLHLDD
AIRGQEDMKE QVAMVERRNG LMVAEIEELR AALEQTERGR KVAEQELVDA SERVGLLHSQ
NTSLLNTKKK LEADLVQVQG EVDDAVQEAR NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL
ERMKKNLEVT VKDLQHRLDE AESLAMKGGK KQLQKLESRV RELEAEVEAE QRRGADAVKG
VRKYERRVKE LTYQTEEDKK NLVRLQDLVD KLQLKVKAYK RQAEEAEEQA NTHMSRLRKV
QHEMEEAQER ADIAESQVNK LRVKSRDAGK VIHVIHFTQN LPLFNGVV
//
