ID I3J1F8_ORENI Unreviewed; 325 AA.
AC I3J1F8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Metaxin {ECO:0000256|PIRNR:PIRNR038150};
GN Name=LOC100689863 {ECO:0000313|Ensembl:ENSONIP00000002698.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002698.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002698.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development. {ECO:0000256|ARBA:ARBA00037753}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294,
CC ECO:0000256|PIRNR:PIRNR038150}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170, ECO:0000256|PIRNR:PIRNR038150}.
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DR RefSeq; XP_003451287.1; XM_003451239.4.
DR AlphaFoldDB; I3J1F8; -.
DR STRING; 8128.ENSONIP00000002698; -.
DR Ensembl; ENSONIT00000002699.2; ENSONIP00000002698.2; ENSONIG00000002166.2.
DR GeneID; 100689863; -.
DR KEGG; onl:100689863; -.
DR CTD; 556917; -.
DR eggNOG; KOG3028; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_5_0_1; -.
DR InParanoid; I3J1F8; -.
DR OMA; TIDYDCA; -.
DR OrthoDB; 2897805at2759; -.
DR TreeFam; TF313422; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF34; METAXIN-1; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787,
KW ECO:0000256|PIRNR:PIRNR038150};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..144
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 175..237
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
SQ SEQUENCE 325 AA; 36908 MW; F373B166897EA53C CRC64;
MAAPDELFCW EGDWGLPSVS TDCLVVLAYA QFAGAPLKLR KISNPWRSPS GSLPALRTNQ
KETLSRPSDI IIHLRKQKFN ADYDLSAKEG ADSLAFISLM EEKLMPALIY TFWIEPKNYV
DVTRRWYAEH MPFPLNFFLP GRMQRQQLEK LRLLRGDERL EAGEELEKEL YRDAVECMNL
LSQRLGSHKF FFGDSPSSLD AYVFGHLAPI LKCKLPNGKL QQHLKSLDNL TNFCTNILQL
YFPKDGRESF SQKTSSQSEG GDFDHVPNKR RKQFLSALVA LGAMLSYALL TGMVSIQHAH
HEALEEPPDL QDIGSHHDHE DEGDG
//
