ID I3J2S2_ORENI Unreviewed; 666 AA.
AC I3J2S2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=ETS-related transcription factor Elf-4 {ECO:0000313|Ensembl:ENSONIP00000003162.2};
GN Name=LOC100712278 {ECO:0000313|Ensembl:ENSONIP00000003162.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003162.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003162.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_005467443.1; XM_005467386.3.
DR RefSeq; XP_005467444.1; XM_005467387.3.
DR RefSeq; XP_005467445.1; XM_005467388.3.
DR RefSeq; XP_005467446.1; XM_005467389.3.
DR RefSeq; XP_005467447.1; XM_005467390.3.
DR AlphaFoldDB; I3J2S2; -.
DR STRING; 8128.ENSONIP00000003162; -.
DR Ensembl; ENSONIT00000003163.2; ENSONIP00000003162.2; ENSONIG00000002525.2.
DR GeneID; 100712278; -.
DR CTD; 1997; -.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000157039; -.
DR HOGENOM; CLU_027279_0_0_1; -.
DR InParanoid; I3J2S2; -.
DR OMA; CSYLFPT; -.
DR OrthoDB; 4245771at2759; -.
DR TreeFam; TF318679; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF170; ETS-RELATED TRANSCRIPTION FACTOR ELF-4; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 222..304
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 185..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 71748 MW; 66775C943DE17700 CRC64;
MTTAVQPSEL VFEFASNGMD EINQVCSYLF PTPGSESCGA GLILDDPSVF PAVIVEQVPA
ADLLQVYSGL ESDEVTNGIM VDTTLHVVEE PSILEGGVDL TETTVSGTED SMETNEAAAA
LLNMESPNNI LDEKRMLHTY GTLLEPDLTY APLRPDQMDS VALDMSVDED TSSMDEIPQK
FPLKPQKKTK VRKPRAVRPC SPITTPNLPL RKKSKEGKGN TIYLWEFLLA LLQDKNTCPK
YIKWTQREKG IFKLVDSKAV SKLWGKHKNK PDMNYETMGR ALRYYYQRGI LAKVEGQRLV
YQFKEMPADL VVIEDEETGS DANVGYGNQR STNGRSVVRG GSKGHGRAHG QQHVSAKQMK
KEPNNECLYQ EANGAQAEQL LQSVHMLQAN QGAGVQETAQ ALRTISTPAS VPMVLTSSGS
LQSVPLTVLA NGDSSHSPSR VILHTMPSTT AGGKDVLTIH TASIAGGANS LQDGLPQQLL
VTSLGSSASS SCTSPPGVIS STASNLNGLP RLVTINTTCG QTMVAQQPGT VIATVLKSSD
LSGLQVKEEM LDPSYFQSMV NGDPSLAAHT FEKEEMEAGE AELQYRTVII DTSQSQGPEG
ASETIINGHS SQSSSPSEGL TPVEELEVRG EMSLQPEQGI KGLQELPVSV QLPANFIQIK
TEPAEA
//
