ID I3J3H2_ORENI Unreviewed; 586 AA.
AC I3J3H2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Ral GEF with PH domain and SH3 binding motif 2 {ECO:0000313|Ensembl:ENSONIP00000003412.1};
GN Name=ralgps2 {ECO:0000313|Ensembl:ENSONIP00000003412.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003412.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003412.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003439939.2; XM_003439891.4.
DR AlphaFoldDB; I3J3H2; -.
DR STRING; 8128.ENSONIP00000003412; -.
DR Ensembl; ENSONIT00000003413.2; ENSONIP00000003412.1; ENSONIG00000002722.2.
DR GeneID; 100702871; -.
DR KEGG; onl:100702871; -.
DR CTD; 55103; -.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000154079; -.
DR HOGENOM; CLU_021333_0_1_1; -.
DR InParanoid; I3J3H2; -.
DR OMA; QAYATTQ; -.
DR OrthoDB; 68574at2759; -.
DR TreeFam; TF352150; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF357; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 51..289
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 460..572
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 65382 MW; E7AEF0BFAF52DBB5 CRC64;
MMDLPNGQSS ISTSAATVSE KSSSSESLSD KGSSELKKSF DAVVFDVLKV TPEEYAGQIT
LMDAPVFKAI QPEELSSCGW NKKEKHSSAP NVVAFTCRFN QTSFWVVREI LHAQTLKIRA
EVLSLYIRTA KKLCDMNNLH AVMAVVSALQ SAPIFRLTKT WALLNRKDKA TFDRLDYLMS
KEDNYKRLRD YISSQSMVSC IPYLGMYLSD LTYIDSAYPS TGSILENEQR SNLMNNILRI
ISDLQRSCTY DIPVLPHIQK YLNSVRYIEE LQKFVEDDNY KLSQKIEPGT STPRANASKE
DLVGQEASAS PLCGRKCAVA PDGTKVPATP PSPRNLLPYG HRKCHSLGYN FIHKTNTVEF
KSATFPNAGS RHLLDDSVME SHSPTRGQAE SSTLSSGISL GSSEGSELSE EMSWPAFERT
RFYHSLGPVT RVARIPYKGV LRPSSSAESE ELAVHLYPGA VTVQGVLRRK TVLKEGKKPT
VASWTKYWVA LCGTQLYYYP AKSLKATERK HFKSTSSKIV CVVGLMAMMA DDPEHPDVFL
LTDSEHGNTY KYQAGNRMNA LLWYKHLSAA CQSNRQQVPA NLMSFE
//
