ID I3J406_ORENI Unreviewed; 971 AA.
AC I3J406;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL1A {ECO:0000313|Ensembl:ENSONIP00000003596.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003596.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003596.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_003439798.1; XM_003439750.3.
DR AlphaFoldDB; I3J406; -.
DR STRING; 8128.ENSONIP00000003596; -.
DR Ensembl; ENSONIT00000003597.2; ENSONIP00000003596.2; ENSONIG00000002872.2.
DR GeneID; 100712257; -.
DR KEGG; onl:100712257; -.
DR CTD; 114876; -.
DR eggNOG; KOG2209; Eukaryota.
DR GeneTree; ENSGT00940000155295; -.
DR HOGENOM; CLU_007105_5_1_1; -.
DR InParanoid; I3J406; -.
DR OMA; AQTCQQK; -.
DR OrthoDB; 960at2759; -.
DR TreeFam; TF320922; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13285; PH_ORP1; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 238..338
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 462..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 109589 MW; 018526475650123E CRC64;
MEELEPEEQF LRYARNGDLP GVQRLLLSKI REEIQLNINC KGKSKYNLGW TPLHLACYFG
HKDVVEELLK AGADVSLPNN IGDTPLHKAA FTGRKEVVML LLHYGACATV INGTAQIPKD
VTQNAEIRSM LEGAERTEER KLEEKLLDAA REGDLSTLTH LLCRKKPPDI NCTDLLGNTP
LHCAAYRGQR QCALKLLKGG ANPNFQNKNG QTVFDLASDT AMKQILEGNF HRGMTRHVKK
YEGPLWKSSR FFGWRSYWVV LQDGVISWYS KQSEAAAGER RQGCKSLTNA HCLIRAKDNC
FFTLKCFDDS VHHFKVSPKN DPEGTRKAWL DALEEHAAYS TYYCSQEQGS EEEEYEEVMS
LGELTSSLQV ADVSQKNLEK EVAALLSMLK NEELSEKFPS TILQKMQEIC ELSSETTSNL
NVCLSLFSRQ EGVRSLKLEQ EVEKNKILSE ALQTLATEHH ELEQSVVKGS SPRSALSEDE
FHDAVSDSES ELSLSGFETV ASQSCEEDED EDEGSVMLSS TCSSPASTLE QDHHGDKAET
QPNGITKHRT SLPAPMFSRN DFSIWSILRN CIGMELSKIT MPVIFNEPLS FLQRLTEYME
HTYLIHQANA SSDSIERMKC VAAFAVSAVA SQWERTGKPF NPLLGETYEL VREDLGFRLI
SEQVSHHPPV SAFHAEGLKQ DFVFHGSIYP KLKFWGKSVE AEPKGTITLE LPKHNEAYTW
TNPTCCVHNI IVGQLWIEQY GNVEVVNHRT GERCYLNFKP CGLFGKELHK VEGYILDKSK
KKLCALYGKW TECLYVVDPS AFEAHKKNNK KGAEDKKGGN AGCAEDQEEV PSPPADTVEV
VPGSQLLWKI APRPANSVQM YNFTCFAMQL NELHKEMEGV IPQTDCRLRP DIRAMENGDI
DLASEEKKRL EEKQRAARKN RSKADEEWKT RSPALGPRWF QQGQNPHTNS QDWLFCGGYW
NRAYSQLPDI Y
//
