ID I3J4R5_ORENI Unreviewed; 2602 AA.
AC I3J4R5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=SET domain containing 2, histone lysine methyltransferase {ECO:0000313|Ensembl:ENSONIP00000003855.2};
GN Name=setd2 {ECO:0000313|Ensembl:ENSONIP00000003855.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003855.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003855.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_019220399.1; XM_019364854.1.
DR STRING; 8128.ENSONIP00000003855; -.
DR Ensembl; ENSONIT00000003856.2; ENSONIP00000003855.2; ENSONIG00000003077.2.
DR GeneID; 100689872; -.
DR CTD; 29072; -.
DR GeneTree; ENSGT00940000166273; -.
DR InParanoid; I3J4R5; -.
DR OMA; VAYDRIQ; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1350..1404
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1406..1523
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1530..1546
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2429..2462
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 64..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..2000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2018..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2458..2503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..333
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1695..1720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1779
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1803..1817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1883..1897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1898..1924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1925..1939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2050..2127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2485..2499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2602 AA; 289509 MW; BE23B63B46743999 CRC64;
MGDPCDLKHF VKEEGSGASV KVEGLSKAAL IKSLSPRVML SNHLLPKGTK MKVNLEDQGR
QKVSFSFSQT KKPLQSPFFI PPSPDKADPH AASSQSTSDK PGKSADSKTE QRQTPLVPAS
KAETPQTPVP TATKVKMMHF KKQILNDSVT EEKQSVMPEE THTSEFQNEL PAPQSLISTC
PSESAHTETS ETRETSSLKK PAASSGKDGE TSSSTEQDEK IHKRKTRSQS DSAPPGSESD
GDSAQMSSSH KSVDSKSKTN SDSRSKDVRK SSSGSHAEER EKSFSKRSEN YERSSSYSKS
DRDSRHTSSR SSRSEKDRRR SRSRSRSRSR GSRTSSSHSR SDRTRSDRGS RSERSYYHES
DWRSHRSSPR RDRRRSRSRT DRTRDSSDSE DDHRKTRSRT SDNSRSSNHS SSHKESKSSS
YSKSEKTSKS VDSPHSSELD KRTQSSKSER STKRLSDSDT LRKCSPDLDS SHRKSSSHHK
SEANNKFSSS SSHTHSQTHE KRQKSSPSDS EMDHKGKLQS SNRSSSSLEN CKNSQKKSSR
PESKQVPSRS SVKSSGQDRQ SDDLFHSPGK APSCATTTES FYQSSKEKSD SQPVGNENGN
KDDKEAGSCG EGSQELSLKT EAKSGLEKEN NIASDVTSSE SLKHLNSTLE NVSNVKDSLS
SNDPTHVNSN GSVVNLCSSN DSTMCNKDKD IFDCSPGPES VLHSVDKAVT EAVQQNTKPE
NVELDKAQTV SKESDTDLPV KSDSSCLQSE NQPESLPTDI KKGSCSTRKS RWDIVGQDSS
ESENSQRTVC VESKLLNTVK KVISVKKIEF SKDNAQQDCD IKDDIQQEAE THSRLVRQTE
ISKQEVQSES TPVTFNCKDQ SEPSQASTSN DHCDSKLSAS QKSNTDQPLH INDKIQINSA
ATAQHSNEEN SENKSKDSAS KSKLSKRMSP SQDASGQSEA SDSDNSEYDS DCGEAIKQLH
SVVVVPKNSC LTMNTEERGP LNILQQQNAI AAEKNISEPP NQVSQQQKQP TTQTSISDSL
SALCQSQSNM IDSTSHSEAT TSISTQPYTS GHTSSHASVT DSTPMLDNSK QCEQGHKQHD
VSNRGDRTHM HYQQDLFSRA DNINEKNEFN LGWDFSQPEQ PSSTYQQPDS SHGPQLTNTK
LSGSFSKGQE QEHRPSIASC IQQSQNMQTS RKNYLHANVN DQDPSGEIHP DSLTNDHDDF
SGDKSSIFSK TAFEGSGPNT QGSSSFVQGH EISSNSRCST VPDPSREDSF RPHRGRGPPK
KRRPEIESDS DNEAEAGPAA KRERQGDTEV AKETLVKSAA DRPSLTLQDF QDANRWKEFA
KSKKMPPYFY LIEDNMYLTE RKKSKSHRDI KRMQCECPVL PREDRARGVL ACGDDCLNRL
LMIECSSRCL NGAYCSNRRF QMKQHADFEV ILTEDKGWGL RAAKDLAPNT FVLEYCGEVL
DHKEFKTRVK EYARNKNIHY YFMSLKNNEI IDATQKGNCS RFMNHSCEPN CETQKWTVNG
QLRVGFFTTK AVTAGTELTF DYQFQRYGKE AQKCFCGAPS CRGFLGGENR VSVRAAGGKM
KKDRSRKSAL TTVDEELEAL LENGEGLYDE KQVVSLCRLM VRVETMEQKL ICLKLIQDTQ
NPSCLKQFLD HHGLSLLWIF MVELSEAKVN SANNIKLQLQ IMKTLSVLPI STKNMLEESR
VLTFIQRWAQ TKTLPQQTEM DGYSSENTSR AQTPLNTPDG SSAKIGPELD SDTSKPAVYR
RLKIISENSL DSALSDASKA SDGKEEEEED DDEEDDENSR AGLPEGKQLK ADTLVDAADP
TTDSAEESGK EVIGEKQEEA AMTSSSEPQP PTEEVKEKPD LVVEEKDSDM KEVKSEDQAD
ELEPPKEPVE TQESGTPQDT ESVTEKAELE EGQPNVKVHE PETQSSQTGV ADAPPEQPSE
TLESQTEAEE AKKTPPSSEP HHGESTTDVP PIAEAPEATI PSEVTATPVD PSVIGTPSQD
EEEGVSDVES ERSQEPQLSV LDISGMAARL LESWKDLKEV YRIPKKTQVD KEGRDRSRDR
DTALTPRTTS GSRERERERE KERERDRDRD YDRDRDRDWD RDRDRDRDRG SEKTPRSSER
RRRRSPSPPS SYERSSRRTE ERFDPSNNSK TPRGVGGKER NKLSTEERRK LFEQEVAQRE
AQKQQQLQQQ QQQQLQSMAY DPALAYASSP GFITYPPGYP IQTFVDPSNP NAGKVLLPTP
SVEPSLNYEQ TPPQRLVSDL GLTSPSSTPQ TTPVTNLPQH VTTANLASGN PQQYAQPTVA
TQDAGVAVLS VPAQSAPQVQ GQQSYTTLWD PTTQQAVTVQ TQPAQQYAAA PGQGQTPTAI
YYQGQPCQTI YSIPAPYPQT NTPVIQAYTD PTASYLHGQP VYPGQQGVVV QQGGTVTTIV
TSQTVQQEMI VPNSVIDLPP PSPPKPKTIV LPPNWKVARD PEGKIYYYHV VTRQTQWDPP
TWEGNSDNTS VDHESEMDLG TPTYDENPSK FSTKTAEADT SSELAKKSKE TFRKEMSQFI
VQCLNPYRKP DCKSGRISNT EDFKHLARKL THGVMNKELK ACKNPEDLEC NENVKHKTKE
YIKKYMQRFG AVYRPKEDTE VY
//
