ID   I3J641_ORENI            Unreviewed;       965 AA.
AC   I3J641;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Coiled-coil domain containing 40 {ECO:0000313|Ensembl:ENSONIP00000004331.2};
GN   Name=ccdc40 {ECO:0000313|Ensembl:ENSONIP00000004331.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004331.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000004331.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_013128473.1; XM_013273019.2.
DR   AlphaFoldDB; I3J641; -.
DR   STRING; 8128.ENSONIP00000004331; -.
DR   Ensembl; ENSONIT00000004333.2; ENSONIP00000004331.2; ENSONIG00000003441.2.
DR   GeneID; 100695485; -.
DR   KEGG; onl:100695485; -.
DR   CTD; 55036; -.
DR   eggNOG; ENOG502QQ91; Eukaryota.
DR   GeneTree; ENSGT00440000035688; -.
DR   HOGENOM; CLU_008826_2_0_1; -.
DR   InParanoid; I3J641; -.
DR   OMA; RMQRIQK; -.
DR   OrthoDB; 314965at2759; -.
DR   TreeFam; TF325559; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0035082; P:axoneme assembly; IEA:Ensembl.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR   GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR037386; CCDC40.
DR   PANTHER; PTHR16275; COILED-COIL DOMAIN-CONTAINING PROTEIN 40; 1.
DR   PANTHER; PTHR16275:SF8; COILED-COIL DOMAIN-CONTAINING PROTEIN 40; 1.
DR   Pfam; PF08647; BRE1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          128..207
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          243..326
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          418..459
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          700..741
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          821..862
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   965 AA;  110738 MW;  B8DA03A941B25CFD CRC64;
     MQNPGDEDGR EESSTRNETE PNLQDGSDDA EEDSGATASH VPEVQSLPQP ESSAAQHYPD
     LTVVDENLPA AINLMQEDVA QVAHRSHTSE EMEDDEPLPE DEEEELIVLD PEHPVVRRQQ
     AALTIQLRKQ LERINQALRE KHAVAKDDAS HNQELGVEVF RLQEQLVRQQ NRLHDLHETK
     TQAEAKHQQA LNQLEEIKSQ HSSMTRKVCE ARANVSQLQA QLDSMTQYLI FIQGVSEGLR
     SEVKTMNNAR RKAGAEKTQA EDQKLKQDLY VERLTKELDR LTQQIAMYEA KTSAQAEETQ
     TAKEALSEAE MEMESLLVAR KQLLQQWNSC LMGLRRRDEA FGAMQEVIRE TKHQVILLDK
     DIDGYKKSIN AEQEQNEILT LQLNWSQMDC TTTRKLISDK QAQQESLQAH YSTFLLTLQE
     TERTLARLSK EFGSHQAQVN DQSKQLEKES SARLELENNI MSSMQHKLLH NSTAKYSQLL
     TEKISRLKKE KMYQLKQSEE EVLVVKLESQ LVSQRVDSLA LTQEALDQEI AKSNKLITAI
     QAKVTSSVRV IEQKQSTIIG YNKKISQIAA STGHDDLGPL HIKIQSIIAQ IEELAANIKS
     YQQLWMKQQG ILMGLTQTIE ANSKELLKLQ TEYTGWQQTK LYFESQIESE HREEAELEKS
     SKMLKRDQLK LNMLLSRKGQ LSQALQQENA VMETDFIHRL KDAEREAVKM QMKLEKTQEE
     KERLLNSLVE AERQIMLWEK KTQLVKEMHS AMDVGQGESH TMKAEIHRME VRLSQLMKQR
     ECLLRESEAT VARRETIVLR KEAMMRNSLK QATQGDLSLS IQGLQRKIRE AHKQVVEYEQ
     VIGELQKQKE SLRDMIAQKK THLTELCSTS YILDSDFVHL QDTKERNLAH LVALQSRAKR
     LRTVCEGSYR TVSTPESVEA ALQRQTERLH AISTILHRVC EEFPQHQGAL RRLSRALSEH
     AKAVE
//