ID I3J6E5_ORENI Unreviewed; 262 AA.
AC I3J6E5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Homeobox protein HMX2 {ECO:0000313|Ensembl:ENSONIP00000004435.2};
GN Name=LOC100701922 {ECO:0000313|Ensembl:ENSONIP00000004435.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004435.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004435.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family.
CC {ECO:0000256|ARBA:ARBA00038165}.
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DR RefSeq; XP_003448105.1; XM_003448057.4.
DR AlphaFoldDB; I3J6E5; -.
DR STRING; 8128.ENSONIP00000004435; -.
DR Ensembl; ENSONIT00000004437.2; ENSONIP00000004435.2; ENSONIG00000003523.2.
DR GeneID; 100701922; -.
DR KEGG; onl:100701922; -.
DR CTD; 751654; -.
DR eggNOG; KOG0485; Eukaryota.
DR GeneTree; ENSGT00940000165038; -.
DR HOGENOM; CLU_064096_3_0_1; -.
DR InParanoid; I3J6E5; -.
DR OMA; KAEAPCR; -.
DR OrthoDB; 414754at2759; -.
DR TreeFam; TF320562; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1900052; P:regulation of retinoic acid biosynthetic process; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46110:SF5; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46110; HOMEOBOX PROTEIN HMX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 131..191
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 133..192
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 50..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 29011 MW; DDDDCC1AC822BBD2 CRC64;
MNKAEAPRRP TASLKFTIDN ILNLKTSGNN CDTCHSAGSQ DELATAMRKD SFHHEEKGTQ
ARQDPDRLND SELITDCSGS TETVVISRGN QRKVTEARFE SGDSSCDDSS SPTAATDAHK
GGSPGKKNKM ITKKKTRTIF SKRQIFQLES TFDMKRYLSS AERACLASSL QLTETQVKIW
FQNRRNKLKR QISNEIEGPV SDFPETGKPV VVGQLPALYK ESNLLGRCLL PVPLPVVYPG
SSTPYLCFSN ASKYFSLYEG DV
//