ID I3J6G2_ORENI Unreviewed; 847 AA.
AC I3J6G2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=LOC100696613 {ECO:0000313|Ensembl:ENSONIP00000004452.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004452.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR RefSeq; XP_003444424.1; XM_003444376.4.
DR AlphaFoldDB; I3J6G2; -.
DR STRING; 8128.ENSONIP00000004452; -.
DR Ensembl; ENSONIT00000004454.2; ENSONIP00000004452.1; ENSONIG00000003535.2.
DR GeneID; 100696613; -.
DR KEGG; onl:100696613; -.
DR CTD; 561469; -.
DR eggNOG; KOG2189; Eukaryota.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; I3J6G2; -.
DR OrthoDB; 1967517at2759; -.
DR TreeFam; TF300346; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF71; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 407..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 546..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 642..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 777..800
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 685..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..126
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 847 AA; 97141 MW; 4D233FFDC82D272A CRC64;
MVFRSEEMCL AQLFLQSGSE YDCISELGEL GLVEFRDLNP SVSSFQRHFV SEIKRCEEME
RILGYLLREI QKAKIAIPQE DESPLAPPPR QVLEIMEQLQ RLEMELSEVA KNKEKLQRNL
LELTEYTHML KITRTFIHSR SRHEALGNQY EEFPTMETDS VTGSTGMQRL GAKLGFVSGL
IQRVKVEAFE RMLWRVCKGY TILSYAEVDE NLADLDTGEI GKSVVFLISF WGDQIGQKVQ
KICDCYHCHL YPHPENDEER ADVLDSLRTR IQDLNNVLHR TEDYLRQVLQ KASESVYTWV
VQVKKMKAIY HILNLCSFDV TNKCLIAEVW CPVSDLANLR GALEEGSRKG DATVPSFVNR
IPSTDTPPTL LRSNKFTAGF QSIVEAYGVG DYREVSPAPY TIITFPFLFA VMFGDLGHGM
VMSLFALWMV LMEKKQKKKR SSNEIWATFF NGRYIILMMG LFSIYTGLIY NDCFSKSLNI
FGSGWSVKAM FTHNQWTNKT LQTNALLTLD PNVSGVFNGP YPFGIDPIWN LAVNRLSFLN
SYKMKMSVVI GVIHMSFGVV LSVFNHLHFR QKFNVYLLFL PELLFLLCLF GYLVFMILYK
WLMFDARYSS QAPSILIHFI NMFVMQGKDI TRLYPGQIGL QIFLLVVAML SVPVLLFGKP
LYLYWLYRGG KGLRRRRGYE RVRRVSEDDG STAPSYDDDD EEEGLDEVTN REALPKEFDF
ADVLLHQAIH TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWDMVMRLG FRITTKVGVV
LLVPVFGLFA TLTVSILLVM EGLSAFLHAL RLHWVEFQNK FYHGTGVKFV PFDFSLLPSV
FEQDGLL
//
